Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 143940..144445 Replicon chromosome
Accession NZ_CP072783
Organism Pseudomonas aeruginosa strain LICME WGH-6

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag J9247_RS00680 Protein ID WP_033968140.1
Coordinates 143940..144221 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag J9247_RS00685 Protein ID WP_057389393.1
Coordinates 144218..144445 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9247_RS00655 (J9247_00655) 139190..140539 + 1350 WP_073648652.1 C4-dicarboxylate transporter DctA -
J9247_RS00660 (J9247_00660) 140589..141275 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
J9247_RS00665 (J9247_00665) 141376..142110 + 735 WP_210224901.1 GntR family transcriptional regulator -
J9247_RS00670 (J9247_00670) 142290..142700 + 411 WP_003110659.1 aegerolysin family protein -
J9247_RS00675 (J9247_00675) 142732..143640 - 909 WP_033977366.1 LysR family transcriptional regulator -
J9247_RS00680 (J9247_00680) 143940..144221 - 282 WP_033968140.1 type II toxin-antitoxin system toxin ParE Toxin
J9247_RS00685 (J9247_00685) 144218..144445 - 228 WP_057389393.1 CopG family ribbon-helix-helix protein Antitoxin
J9247_RS00690 (J9247_00690) 144621..145241 - 621 WP_033968139.1 hypothetical protein -
J9247_RS00695 (J9247_00695) 145342..145842 + 501 WP_003101228.1 LEA type 2 family protein -
J9247_RS00700 (J9247_00700) 145915..146256 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
J9247_RS00705 (J9247_00705) 146340..147767 - 1428 WP_003083784.1 GABA permease -
J9247_RS00710 (J9247_00710) 147936..149429 - 1494 WP_023115963.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10429.16 Da        Isoelectric Point: 9.6558

>T198695 WP_033968140.1 NZ_CP072783:c144221-143940 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQEVANQGAGRPSEVPGVRTLPLERWPFSAPFRVKGKE
IQILRIDRVEIAP

Download         Length: 282 bp

>T198695 NZ_CP096956:3660575-3661153 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTGTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTCCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAGGCCGCGCACCCGGACAAAGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCACCTCGACGC
TCCGCTGCGCGACCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGTCCGCCGAAGCCCTGGCAGTGAAGGCCC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGCTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGTTCGGCGCGACGCCTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8542.56 Da        Isoelectric Point: 5.5656

>AT198695 WP_057389393.1 NZ_CP072783:c144445-144218 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLDHTEIEKRWGLQ

Download         Length: 228 bp

>AT198695 NZ_CP096956:3659932-3660486 [Pseudomonas aeruginosa]
ATGACCGAGCCTCTCCCTTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCACCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAGTCCGGTACCCAGGCGCTGCTGGTGGAGGAAC
GGGCACGCCTGGAGCGTCTGCTCGGCGCCCGCCTGGAAGCCGCCGCCGACCAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCCTGTTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
GCCTCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCACCGCCGGCGCTGGAGTTCGCCAGCGGAGCGAACGCCTCGGCCATAGTGCCGATC
CGGCGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGACGGACGCGCGGTGCGCCTGGTGGAAACCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References