Detailed information of TA system TA198691

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3384726..3386448
• Replicon: chromosome
• Accession: NZ_CP072779
• Organism: Proteus mirabilis strain 1035

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: D0FZT9
• Locus tag: J8N15_RS15790
• Protein ID: WP_000356587.1
• Coordinates: 3384726..3385664 (-)
• Length: 313 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: J8N15_RS15795
• Protein ID: WP_048608544.1
• Coordinates: 3385657..3386448 (-)
• Length: 264 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J8N15_RS15770 (J8N15_15770)	3380667..3381179	-	513	WP_172689549.1	S26 family signal peptidase	-
J8N15_RS15775 (J8N15_15775)	3381163..3381510	-	348	WP_048608540.1	hypothetical protein	-
J8N15_RS15780 (J8N15_15780)	3381503..3383902	-	2400	WP_048608542.1	type IV secretion system protein TraC	-
J8N15_RS15785 (J8N15_15785)	3383902..3384594	-	693	WP_001228924.1	DsbC family protein	-
J8N15_RS15790 (J8N15_15790)	3384726..3385664	-	939	WP_000356587.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
J8N15_RS15795 (J8N15_15795)	3385657..3386448	-	792	WP_048608544.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
J8N15_RS15800 (J8N15_15800)	3386669..3387055	-	387	WP_000180225.1	TraA family conjugative transfer protein	-
J8N15_RS15805 (J8N15_15805)	3387052..3387624	-	573	WP_139175592.1	type IV conjugative transfer system lipoprotein TraV	-
J8N15_RS15810 (J8N15_15810)	3387699..3388988	-	1290	WP_210234515.1	TraB/VirB10 family protein	-
J8N15_RS15815 (J8N15_15815)	3388991..3389887	-	897	WP_210234582.1	type-F conjugative transfer system secretin TraK	-
J8N15_RS15820 (J8N15_15820)	3389871..3390497	-	627	WP_210234516.1	TraE/TraK family type IV conjugative transfer system protein	-
J8N15_RS15825 (J8N15_15825)	3390494..3390775	-	282	WP_000433891.1	type IV conjugative transfer system protein TraL	-
J8N15_RS15830 (J8N15_15830)	3390956..3391279	+	324	WP_210234517.1	type II toxin-antitoxin system RelE/ParE family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(J) / sul2 / aph(3'')-Ib / aph(3')-VIb / blaPER-1 / aph(6)-Id / aac(3)-IId / erm(42)	-	3292765..3481590	188825

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-97)

Sequences

Toxin

Protein

• Length: 313 a.a.
• Molecular weight: 35548.82 Da
• Isoelectric Point: 4.9081

>T198691 WP_000356587.1 NZ_CP072779:c3385664-3384726 [Proteus mirabilis]
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLIELQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE

Nucleotide

• Length: 939 bp

>T198691 NZ_CP096953:c4771268-4770513 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATATCCGACCGCTCCAGGGGCGCCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGCTGGGGG
TCGCGGTTTGGCCGTCGCCACGAGCCAAGCCTGTTCTACGCCGCGTTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGCGTCCTGTGGAGTGGCATGGCGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATCCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGAACTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin

Protein

• Length: 264 a.a.
• Molecular weight: 30100.44 Da
• Isoelectric Point: 9.3513

>AT198691 WP_048608544.1 NZ_CP072779:c3386448-3385657 [Proteus mirabilis]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPDAQGDIKPTWVDAIQALDVQLGVSVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG

Nucleotide

• Length: 792 bp

>AT198691 NZ_CP096953:c4771771-4771403 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGTCCCAGCGCCGATGCCGTCCTGGCCAAGGCCGTCCTGGCCGCGCGCGAGCAATTGGG
GCTGACGCAGCTCGAACTGGCCGGCATCGTCGGCGTCGATCGCAGCGCCATCAGCCGCTGGAAGACCCAGGGCCTGCGGG
TGGACAGCAAGACCGGCGAGCTGGCTCTGCTGCTGGTGCGAGTCTATCGCGCACTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACATGCGCCACTTCCTGCGCACTCCCAACCATCACCTGGCGGGCGAGCCGCTGGCACTGATGGGACAGGTGCAGGG
CCTGGTTCATGTGCTGGAATACCTCGATGCGATCCGCGGCAAGGTCTGA

Structures

Toxin

• AlphaFold DB: A0A1U9VZ44