Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc-RelB |
| Location | 14599..15200 | Replicon | chromosome |
| Accession | NZ_CP072779 | ||
| Organism | Proteus mirabilis strain 1035 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | - |
| Locus tag | J8N15_RS00065 | Protein ID | WP_049194960.1 |
| Coordinates | 14599..14982 (-) | Length | 128 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | A0A1Z1SPN9 |
| Locus tag | J8N15_RS00070 | Protein ID | WP_004246496.1 |
| Coordinates | 14979..15200 (-) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J8N15_RS00040 (J8N15_00040) | 9971..10429 | + | 459 | WP_004249766.1 | GNAT family N-acetyltransferase | - |
| J8N15_RS00045 (J8N15_00045) | 10525..11262 | - | 738 | WP_004249950.1 | tetratricopeptide repeat protein | - |
| J8N15_RS00050 (J8N15_00050) | 11371..12270 | + | 900 | WP_109023958.1 | N-acetylmuramic acid 6-phosphate etherase | - |
| J8N15_RS00055 (J8N15_00055) | 12627..13616 | - | 990 | WP_241161403.1 | HipA domain-containing protein | - |
| J8N15_RS00060 (J8N15_00060) | 13878..14192 | - | 315 | WP_004246498.1 | helix-turn-helix transcriptional regulator | - |
| J8N15_RS00065 (J8N15_00065) | 14599..14982 | - | 384 | WP_049194960.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| J8N15_RS00070 (J8N15_00070) | 14979..15200 | - | 222 | WP_004246496.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| J8N15_RS00075 (J8N15_00075) | 15481..16344 | - | 864 | WP_004249947.1 | YicC/YloC family endoribonuclease | - |
| J8N15_RS00080 (J8N15_00080) | 16471..17187 | + | 717 | WP_004249946.1 | ribonuclease PH | - |
| J8N15_RS00085 (J8N15_00085) | 17268..17912 | + | 645 | WP_004246493.1 | orotate phosphoribosyltransferase | - |
| J8N15_RS00090 (J8N15_00090) | 18231..18836 | - | 606 | WP_004246491.1 | nucleoid occlusion factor SlmA | - |
| J8N15_RS00095 (J8N15_00095) | 18956..19414 | - | 459 | WP_004246490.1 | dUTP diphosphatase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 128 a.a. Molecular weight: 14462.43 Da Isoelectric Point: 6.6451
>T198690 WP_049194960.1 NZ_CP072779:c14982-14599 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQHFPGVAGMSDPGRAEALIYRVQNRKHDEGITDVFELAATYWVAIARGHIFNDGNKRTAFFVT
MTFLYRNGIRIRDTDNMLENLTVEAATGEKTVDQLAKHLQNLVEKTN
MIWVSAQEVIAFHDRILQHFPGVAGMSDPGRAEALIYRVQNRKHDEGITDVFELAATYWVAIARGHIFNDGNKRTAFFVT
MTFLYRNGIRIRDTDNMLENLTVEAATGEKTVDQLAKHLQNLVEKTN
Download Length: 384 bp
>T198690 NZ_CP096953:3829990-3830568 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTGTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTCCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAGGCCGCGCACCCGGACAAAGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCACCTCGACGC
GCCGCTGCGCGACCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGTCCGCCGAAGCCCTGGCAGTGAAGGCCC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGCTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTGTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTCCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAGGCCGCGCACCCGGACAAAGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCACCTCGACGC
GCCGCTGCGCGACCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGTCCGCCGAAGCCCTGGCAGTGAAGGCCC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGCTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG
Antitoxin
Download Length: 74 a.a. Molecular weight: 8260.23 Da Isoelectric Point: 5.5667
>AT198690 WP_004246496.1 NZ_CP072779:c15200-14979 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR
Download Length: 222 bp
>AT198690 NZ_CP096953:3829347-3829901 [Pseudomonas aeruginosa]
ATGACCGAGCCTCTCCCTTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCACCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAGTCCGGTACCCAGGCGCTGCTGGTGGAGGAAC
GGGCACGCCTGGAGCGTCTGCTCGGCGCCCGCCTGGAAGCCGCCGCCGACCAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCCTGTTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
GCCTCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCACCGCCGGCGCTGGAGTTCGCCAGCGGAGCGAACGCCTCGGCCATCGTGCCGATC
CGGCGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGACGGACGCGCGGTGCGCCTGGTGGAAACCCTCTGA
ATGACCGAGCCTCTCCCTTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCACCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAGTCCGGTACCCAGGCGCTGCTGGTGGAGGAAC
GGGCACGCCTGGAGCGTCTGCTCGGCGCCCGCCTGGAAGCCGCCGCCGACCAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCCTGTTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
GCCTCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCACCGCCGGCGCTGGAGTTCGCCAGCGGAGCGAACGCCTCGGCCATCGTGCCGATC
CGGCGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGACGGACGCGCGGTGCGCCTGGTGGAAACCCTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|