Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2348223..2349198 Replicon chromosome
Accession NZ_CP072769
Organism Bacillus cereus strain BC07

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A7U6C7L7
Locus tag J8Y17_RS12325 Protein ID WP_002021399.1
Coordinates 2348223..2348960 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1J9W3Q2
Locus tag J8Y17_RS12330 Protein ID WP_000594606.1
Coordinates 2349073..2349198 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8Y17_RS12295 (J8Y17_12295) 2343298..2344008 + 711 WP_211480060.1 class I SAM-dependent methyltransferase -
J8Y17_RS12300 (J8Y17_12300) 2344128..2344535 + 408 WP_000072487.1 VOC family protein -
J8Y17_RS12305 (J8Y17_12305) 2344641..2344733 + 93 Protein_2343 methyltransferase -
J8Y17_RS12310 (J8Y17_12310) 2344855..2346540 - 1686 WP_088667017.1 alpha-keto acid decarboxylase family protein -
J8Y17_RS12315 (J8Y17_12315) 2346647..2347129 + 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
J8Y17_RS12320 (J8Y17_12320) 2347297..2348034 + 738 WP_088312955.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
J8Y17_RS12325 (J8Y17_12325) 2348223..2348960 + 738 WP_002021399.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
J8Y17_RS12330 (J8Y17_12330) 2349073..2349198 + 126 WP_000594606.1 hypothetical protein Antitoxin
J8Y17_RS12335 (J8Y17_12335) 2349274..2349450 + 177 WP_000852618.1 stage II sporulation protein SB -
J8Y17_RS12340 (J8Y17_12340) 2349594..2351063 + 1470 WP_193109129.1 beta-Ala-His dipeptidase -
J8Y17_RS12345 (J8Y17_12345) 2351644..2352114 - 471 WP_000771836.1 DUF5065 family protein -
J8Y17_RS12350 (J8Y17_12350) 2352569..2353228 + 660 WP_211480061.1 CatB-related O-acetyltransferase -
J8Y17_RS12355 (J8Y17_12355) 2353557..2354177 + 621 WP_116869360.1 SGNH/GDSL hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28331.03 Da        Isoelectric Point: 8.2638

>T198687 WP_002021399.1 NZ_CP072769:2348223-2348960 [Bacillus cereus]
VISNIRIGLFILAIVFLVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T198687 NZ_CP096952:15499-15774 [Pseudomonas aeruginosa]
ATGGAGTTGAAGTGGACGAGCAAAGGGCTCTCCGACGTGGCACGGCTCTACGAGTTCCTGGCTACGGTGAACAAGGCCGC
AGCCGCCCGCACGGTGCAGCAGCTGACGAGCGCGCCGACCGCCTTGTTGACCAACCCTCGGCTGGGCGAGCGCCTGGAAG
AGTTCGAACCGCGGGATGTTCGCCGCATCCTGATCGGCCACTATGAGATGCGCTATGAGATCCTGGACTCGTGCGTCTAC
GTGCTTCGTCTGTGGCACACACGCGAAGACAGGTAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4860.23 Da        Isoelectric Point: 3.9507

>AT198687 WP_000594606.1 NZ_CP072769:2349073-2349198 [Bacillus cereus]
VIKNNDNDFFKEDNEDTTDFSLIKGDTLQQVEDLEDELKRK

Download         Length: 126 bp

>AT198687 NZ_CP096952:15224-15499 [Pseudomonas aeruginosa]
ATGAGCACAGCAGCCAAACCAACGCGCACCGTGACTGCTCACGTCCCGGTAGATCTGGCCGAGCGCGTCGATGCAATCGC
CGAGCGCCTGGAGCGATCGAAGAACTGGATCGTCAGGCAGGCGCTGTCAGCCTGGATCGACCAGGAAGACGAGCGCAGCC
GTCTGACACGTGAAGCCCTGGATGATGTAGACGCAGGACGTGTCGTCGATCACCAGGCCGTGCAGGCCTGGGCCGAGAGC
TTGGGCACTGACTCTCCGCTGCCGGTACCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U6C7L7

Antitoxin

Source ID Structure
AlphaFold DB A0A1J9W3Q2

References