Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 3831325..3832010 Replicon chromosome
Accession NZ_CP072765
Organism Mycobacterium tuberculosis strain H37Rv_CG

Toxin (Protein)


Gene name vapC Uniprot ID P9WF49
Locus tag J8668_RS17875 Protein ID WP_003917170.1
Coordinates 3831600..3832010 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J8668_RS17870 Protein ID WP_003912220.1
Coordinates 3831325..3831603 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8668_RS17850 (J8668_17850) 3827314..3828915 - 1602 WP_003417969.1 FAD/NAD(P)-binding protein -
J8668_RS17855 (J8668_17855) 3828932..3829636 - 705 WP_003417980.1 dTDP-4-amino-4,6-dideoxyglucose formyltransferase -
J8668_RS17860 (J8668_17860) 3829754..3830320 - 567 WP_003417984.1 TetR/AcrR family transcriptional regulator -
J8668_RS17865 (J8668_17865) 3830382..3831269 + 888 WP_003900050.1 alpha-ketoglutarate-dependent sulfate ester dioxygenase -
J8668_RS17870 (J8668_17870) 3831325..3831603 + 279 WP_003912220.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
J8668_RS17875 (J8668_17875) 3831600..3832010 + 411 WP_003917170.1 type II toxin-antitoxin system VapC family toxin Toxin
J8668_RS17880 (J8668_17880) 3832043..3833779 - 1737 WP_003418002.1 cholesterol oxidase -
J8668_RS17885 (J8668_17885) 3833835..3834962 - 1128 WP_003418005.1 GuaB3 family IMP dehydrogenase-related protein -
J8668_RS17890 (J8668_17890) 3834982..3836571 - 1590 WP_003900682.1 IMP dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-118)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-54)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14669.76 Da        Isoelectric Point: 5.1784

>T198683 WP_003917170.1 NZ_CP072765:3831600-3832010 [Mycobacterium tuberculosis]
VIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVESMRVVARYGQPGQTERARYLLDGLDILPLTEPVIG
LAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Download         Length: 411 bp

>T198683 NZ_CP096950:c5532241-5531951 [Pseudomonas aeruginosa]
ATGACCGAGCAAATTTATGATTATGACCCCGCGCAAGCGCTGGACAGCCCGGAGGCCATGGCTCTGTTCATCGCAGACGC
CTTGGATACTGGAGACACCGCCTATATCGCTAAGGCTATGGGCGTCGTGGCCCGCGCCAAGGGGATGACGGAGTTGGCCA
AGGAAACGGGTTTGGCCAGGGAGCAGCTTTACAAATCGTTTAGTGAGCGCGGGAACCCTACATTGAAAACCATGCTGGCA
GTAATGCGAGCTCTGGGAGTTGATCTGACCGCCCGCCCGCATGCTCAGTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10280.75 Da        Isoelectric Point: 10.1819

>AT198683 WP_003912220.1 NZ_CP072765:3831325-3831603 [Mycobacterium tuberculosis]
VEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEPARGRKRT
LSDVLNEMRDEQ

Download         Length: 279 bp

>AT198683 NZ_CP096950:c5532537-5532238 [Pseudomonas aeruginosa]
ATGGTCGAAGTCAAACAAACCGCCACTTTCATGGCATGGGAAAGCAAGCTAAAGGATCGGCGGGCAAAGGCCGTGATCGC
CGCCCGTATCTTCCGATTGGCGAATGGACTACCCGGCGATGTGTCACCAGTCGGCCAGGGTGTGAGCGAGTTGAGGATTC
ACTATGGCCCAGGCTATCGGGTGTACTTCCAGCAGCGCGGGACGGAAATCGTCATCCTGCTATGTGGTGGAGACAAGAGC
AGCCAGGCCAGGGATATAGAAATGGCGAAACGCCTGGCAAATGAATGGAGGCCGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A5U883

Antitoxin

Source ID Structure

References