Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3712685..3713359 Replicon chromosome
Accession NZ_CP072765
Organism Mycobacterium tuberculosis strain H37Rv_CG

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag J8668_RS17445 Protein ID WP_003417282.1
Coordinates 3712685..3713113 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag J8668_RS17450 Protein ID WP_003417286.1
Coordinates 3713117..3713359 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8668_RS17420 (J8668_17420) 3708507..3708908 - 402 WP_003417264.1 cytidine deaminase -
J8668_RS17425 (J8668_17425) 3709145..3709483 + 339 WP_003417267.1 succinate dehydrogenase, cytochrome b556 subunit -
J8668_RS17430 (J8668_17430) 3709480..3709914 + 435 WP_009936281.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
J8668_RS17435 (J8668_17435) 3710043..3711815 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
J8668_RS17440 (J8668_17440) 3711815..3712606 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
J8668_RS17445 (J8668_17445) 3712685..3713113 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
J8668_RS17450 (J8668_17450) 3713117..3713359 - 243 WP_003417286.1 CopG family transcriptional regulator Antitoxin
J8668_RS17455 (J8668_17455) 3713481..3714095 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
J8668_RS17460 (J8668_17460) 3714092..3714757 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
J8668_RS17465 (J8668_17465) 3714758..3715291 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
J8668_RS17470 (J8668_17470) 3715288..3715422 - 135 Protein_3487 4a-hydroxytetrahydrobiopterin dehydratase -
J8668_RS17475 (J8668_17475) 3715476..3716737 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T198680 WP_003417282.1 NZ_CP072765:c3713113-3712685 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T198680 NZ_CP072765:c3713113-3712685 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT198680 WP_003417286.1 NZ_CP072765:c3713359-3713117 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT198680 NZ_CP072765:c3713359-3713117 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References