Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3182534..3183082 Replicon chromosome
Accession NZ_CP072765
Organism Mycobacterium tuberculosis strain H37Rv_CG

Toxin (Protein)


Gene name relE Uniprot ID G0TFG5
Locus tag J8668_RS15040 Protein ID WP_003414602.1
Coordinates 3182819..3183082 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O33347
Locus tag J8668_RS15035 Protein ID WP_003414599.1
Coordinates 3182534..3182815 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8668_RS15010 (J8668_15010) 3178157..3179014 - 858 WP_003899513.1 type I methionyl aminopeptidase -
J8668_RS15015 (J8668_15015) 3179056..3179640 - 585 WP_003899514.1 DUF1707 domain-containing protein -
J8668_RS15020 (J8668_15020) 3179744..3179992 + 249 WP_003913411.1 antitoxin VapB23 -
J8668_RS15025 (J8668_15025) 3179989..3180369 + 381 WP_003414592.1 type II toxin-antitoxin system VapC family toxin -
J8668_RS15030 (J8668_15030) 3180451..3182262 - 1812 WP_003414596.1 penicillin-binding protein -
J8668_RS15035 (J8668_15035) 3182534..3182815 + 282 WP_003414599.1 type II toxin-antitoxin system antitoxin RelF Antitoxin
J8668_RS15040 (J8668_15040) 3182819..3183082 + 264 WP_003414602.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J8668_RS15045 (J8668_15045) 3183455..3184309 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
J8668_RS15050 (J8668_15050) 3184365..3185528 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
J8668_RS15055 (J8668_15055) 3185545..3186759 - 1215 WP_003899518.1 zinc metalloprotease Rip -
J8668_RS15060 (J8668_15060) 3186767..3188008 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10204.82 Da        Isoelectric Point: 11.5078

>T198677 WP_003414602.1 NZ_CP072765:3182819-3183082 [Mycobacterium tuberculosis]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Download         Length: 264 bp

>T198677 NZ_CP096950:c160008-159727 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10183.40 Da        Isoelectric Point: 4.3440

>AT198677 WP_003414599.1 NZ_CP072765:3182534-3182815 [Mycobacterium tuberculosis]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Download         Length: 282 bp

>AT198677 NZ_CP096950:c160232-160005 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3G5O

Antitoxin

Source ID Structure
PDB 3G5O
AlphaFold DB A0A7U4BWP8

References