Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-VapB |
| Location | 3075167..3075846 | Replicon | chromosome |
| Accession | NZ_CP072765 | ||
| Organism | Mycobacterium tuberculosis strain H37Rv_CG | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | P9WF90 |
| Locus tag | J8668_RS14475 | Protein ID | WP_003414059.1 |
| Coordinates | 3075167..3075583 (-) | Length | 139 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | G0TF64 |
| Locus tag | J8668_RS14480 | Protein ID | WP_003414061.1 |
| Coordinates | 3075580..3075846 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J8668_RS14455 (J8668_14455) | 3071219..3072121 | - | 903 | WP_003900564.1 | 4-hydroxy-tetrahydrodipicolinate synthase | - |
| J8668_RS14460 (J8668_14460) | 3072190..3072942 | - | 753 | WP_003899465.1 | FAD-dependent thymidylate synthase | - |
| J8668_RS20860 | 3072969..3073106 | - | 138 | Protein_2888 | type II toxin-antitoxin system VapC family toxin | - |
| J8668_RS14465 (J8668_14465) | 3073186..3073461 | - | 276 | WP_003414055.1 | type I restriction endonuclease subunit S | - |
| J8668_RS14470 (J8668_14470) | 3073458..3075080 | - | 1623 | WP_003906897.1 | class I SAM-dependent DNA methyltransferase | - |
| J8668_RS14475 (J8668_14475) | 3075167..3075583 | - | 417 | WP_003414059.1 | type II toxin-antitoxin system toxin ribonuclease C21 | Toxin |
| J8668_RS14480 (J8668_14480) | 3075580..3075846 | - | 267 | WP_003414061.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| J8668_RS14485 (J8668_14485) | 3075872..3076267 | - | 396 | WP_003414064.1 | type II toxin-antitoxin system VapC family toxin | - |
| J8668_RS14490 (J8668_14490) | 3076264..3076533 | - | 270 | WP_003414066.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| J8668_RS14495 (J8668_14495) | 3076543..3077637 | - | 1095 | WP_003414068.1 | restriction endonuclease subunit S | - |
| J8668_RS14500 (J8668_14500) | 3077634..3078053 | - | 420 | WP_003414070.1 | winged helix-turn-helix domain-containing protein | - |
| J8668_RS20865 | 3078052..3078126 | + | 75 | Protein_2897 | hypothetical protein | - |
| J8668_RS14505 (J8668_14505) | 3078127..3078606 | - | 480 | WP_003414073.1 | dihydrofolate reductase | - |
| J8668_RS14510 (J8668_14510) | 3078677..3079477 | - | 801 | WP_003911953.1 | thymidylate synthase | - |
| J8668_RS14515 (J8668_14515) | 3079633..3080370 | + | 738 | WP_003414079.1 | dienelactone hydrolase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15773.00 Da Isoelectric Point: 7.1294
>T198672 WP_003414059.1 NZ_CP072765:c3075583-3075167 [Mycobacterium tuberculosis]
MTTRYLLDKSAAYRAHLPAVRHRLEPLMERGLLARCGITDLEFGVSARSREDHRTLGTYRRDALEYVNTPDTVWVRAWEI
QEALTDKGFHRSVKIPDLIIAAVAEHHGIPVMHYDQDFERIAAITRQPVEWVVAPGTA
MTTRYLLDKSAAYRAHLPAVRHRLEPLMERGLLARCGITDLEFGVSARSREDHRTLGTYRRDALEYVNTPDTVWVRAWEI
QEALTDKGFHRSVKIPDLIIAAVAEHHGIPVMHYDQDFERIAAITRQPVEWVVAPGTA
Download Length: 417 bp
>T198672 NZ_CP096946:c179329-179048 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGATAGGGTCGAAATTACCCCCTGA
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGATAGGGTCGAAATTACCCCCTGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9493.77 Da Isoelectric Point: 7.2783
>AT198672 WP_003414061.1 NZ_CP072765:c3075846-3075580 [Mycobacterium tuberculosis]
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA
Download Length: 267 bp
>AT198672 NZ_CP096946:c179553-179326 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|