Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2935067..2935781 Replicon chromosome
Accession NZ_CP072765
Organism Mycobacterium tuberculosis strain H37Rv_CG

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag J8668_RS13655 Protein ID WP_003413460.1
Coordinates 2935341..2935781 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag J8668_RS13650 Protein ID WP_003413456.1
Coordinates 2935067..2935354 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8668_RS13615 (J8668_13615) 2930489..2930734 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
J8668_RS13620 (J8668_13620) 2930731..2931135 + 405 WP_003899389.1 type II toxin-antitoxin system VapC family toxin -
J8668_RS13625 (J8668_13625) 2931352..2931972 + 621 WP_003413441.1 DUF4178 domain-containing protein -
J8668_RS13630 (J8668_13630) 2931983..2932477 + 495 WP_003413444.1 DUF2617 family protein -
J8668_RS13635 (J8668_13635) 2932474..2932905 + 432 WP_003899390.1 DUF4247 domain-containing protein -
J8668_RS13640 (J8668_13640) 2932960..2933388 + 429 WP_178121172.1 DUF350 domain-containing protein -
J8668_RS13645 (J8668_13645) 2933385..2934956 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
J8668_RS13650 (J8668_13650) 2935067..2935354 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
J8668_RS13655 (J8668_13655) 2935341..2935781 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
J8668_RS13660 (J8668_13660) 2935802..2936557 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
J8668_RS13665 (J8668_13665) 2936690..2937286 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
J8668_RS13670 (J8668_13670) 2937294..2938139 - 846 WP_003413466.1 acyl-CoA thioesterase II -
J8668_RS13675 (J8668_13675) 2938168..2939067 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
J8668_RS13680 (J8668_13680) 2939195..2939869 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T198670 WP_003413460.1 NZ_CP072765:2935341-2935781 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T198670 NZ_CP096945:c5138166-5137819 [Pseudomonas aeruginosa]
ATGTCCCCGGTCGTCATTCGTTTTACTGATACCGCAGAGCAAAGCATCGAAGACCAAGTCCACCACTTGGCTCCATTCCA
AGGTGAACAGGCTGCATTCCAGTCAGTACTGAGCCTTTTGGATGAGATTGAAGAGAAGATTTCACTTGCACCTAAAGGTT
ACCCAGTCAGCCAGCAGGCGAGTCTTCTGGGGGTGCTGAGCTATCGCGAGCTTAATACCGGCCCCTATCGTGTTTTTTAC
GAATTCCACGAAGAGCAAGGCGAGGCGGCAGTGATCTTGGTTCTGCGACAGAAGCAGAGCGTTGAGCAGCAATTGATCCG
CTACTGCTTGGTGGGGCCAATCGAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT198670 WP_003413456.1 NZ_CP072765:2935067-2935354 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT198670 NZ_CP096945:c5138427-5138176 [Pseudomonas aeruginosa]
ATGCGAGTCGAGACAATTAGTTATTTGAAACGTCATGCGGCTGACCTGGATTTATCCGAGCCAATGGTCGTCACGCAGAA
CGGTGTTCCTGCCTATGTGGTTGAGTCATATGCTGAGCGGAAGCAGCGCGATGAAGCAATTGCGCTGGTGAAGTTGCTTG
CGATTGGCTCCCGCCAGTACGCAGAAGGCAAGCATCGCTCTGTTGATGATTTGAAAGCTCGCCTTTCCAGGAGGTTCGCT
CAGCCAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References