Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2235670..2236568 Replicon chromosome
Accession NZ_CP072765
Organism Mycobacterium tuberculosis strain H37Rv_CG

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag J8668_RS10390 Protein ID WP_003410001.1
Coordinates 2235670..2236230 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag J8668_RS10395 Protein ID WP_003410003.1
Coordinates 2236227..2236568 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8668_RS10360 (J8668_10360) 2230839..2231492 - 654 WP_003409976.1 cutinase Cfp21 -
J8668_RS10365 (J8668_10365) 2231607..2231837 + 231 WP_003409980.1 DUF167 domain-containing protein -
J8668_RS10370 (J8668_10370) 2231922..2232833 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
J8668_RS10375 (J8668_10375) 2232942..2233541 + 600 WP_003409989.1 L-lysine exporter -
J8668_RS10380 (J8668_10380) 2233957..2234385 + 429 WP_003409992.1 cellulose-binding protein -
J8668_RS10385 (J8668_10385) 2234611..2235150 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
J8668_RS10390 (J8668_10390) 2235670..2236230 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
J8668_RS10395 (J8668_10395) 2236227..2236568 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
J8668_RS10400 (J8668_10400) 2236654..2236911 + 258 WP_003410006.1 hypothetical protein -
J8668_RS10405 (J8668_10405) 2236812..2237147 - 336 WP_003410009.1 dehydrogenase -
J8668_RS10410 (J8668_10410) 2237236..2237580 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
J8668_RS10415 (J8668_10415) 2237574..2237822 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
J8668_RS10420 (J8668_10420) 2237922..2240237 - 2316 WP_003899120.1 cation transporter ATPase CptG -
J8668_RS10425 (J8668_10425) 2240234..2240506 - 273 WP_003410017.1 DUF1490 family protein -
J8668_RS10430 (J8668_10430) 2240559..2240915 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T198658 WP_003410001.1 NZ_CP072765:c2236230-2235670 [Mycobacterium tuberculosis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T198658 NZ_CP096942:c3640923-3640642 [Pseudomonas aeruginosa]
ATGACCTATGAGCTGGAGTTCCTGCCCTCAGCCCTGAAGGAGTGGCAGAAGCTCGGCCATACGGTGCGCGAGCAGATCAA
AAAGAAACTGCGCGAGCGCCTGGATAATCCCAAGGTTCAGGCCGACGCCCTCAGGGATATGCCGGGGCACTACAAAATCA
AGCTGCGTGCATCGGGCTATCGCCTGGTATACCGCGTCGAAGATGAGCGCGTGGTGGTCGTGGTGGTTGCCGTTGGCAAG
CGCGAGCGCGGGGCCGCTTACCAATCTGCCAAGGGCCGTTAG

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT198658 WP_003410003.1 NZ_CP072765:c2236568-2236227 [Mycobacterium tuberculosis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT198658 NZ_CP096942:c3641158-3640913 [Pseudomonas aeruginosa]
ATGCAGAGTATCTTGGCTGACGTCGCTGTCAGCGTTTCTGAGTTGAAGAAAAATCCGTCGGGCATCCTGGCTGGTGCAGG
TGGTATGCCTGTCGCCGTGCTCAACCACAATCGCGTCATGGGATACATGGTGCCGGCAGAGCTCTATGAGCAGATGATGG
AGCGCCTAGATGATCTGGAGTTGGTCGAAATAGTGAAGGCTCGCTCGGGCGAGGAGTCTGTCCCGGTGCGTTTGGATGAC
CTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References