Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1969277..1969737 Replicon chromosome
Accession NZ_CP072765
Organism Mycobacterium tuberculosis strain H37Rv_CG

Toxin (Protein)


Gene name vapC Uniprot ID G0TKL9
Locus tag J8668_RS09120 Protein ID WP_003898996.1
Coordinates 1969489..1969737 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag J8668_RS09115 Protein ID WP_003408528.1
Coordinates 1969277..1969489 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8668_RS09100 (J8668_09100) 1965755..1966942 - 1188 WP_003898992.1 nitrate transporter NarK -
J8668_RS09105 (J8668_09105) 1967229..1967513 + 285 WP_003408522.1 DUF1876 domain-containing protein -
J8668_RS09110 (J8668_09110) 1967527..1969209 - 1683 WP_003916850.1 SulP family inorganic anion transporter -
J8668_RS09115 (J8668_09115) 1969277..1969489 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
J8668_RS09120 (J8668_09120) 1969489..1969737 + 249 WP_003898996.1 type II toxin-antitoxin system VapC family toxin Toxin
J8668_RS09125 (J8668_09125) 1969745..1970482 + 738 WP_003898997.1 hypothetical protein -
J8668_RS09130 (J8668_09130) 1970576..1972276 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
J8668_RS09135 (J8668_09135) 1972561..1972962 - 402 WP_003408538.1 hypothetical protein -
J8668_RS09140 (J8668_09140) 1972952..1973563 - 612 WP_003898999.1 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8884.14 Da        Isoelectric Point: 4.1074

>T198653 WP_003898996.1 NZ_CP072765:1969489-1969737 [Mycobacterium tuberculosis]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Download         Length: 249 bp

>T198653 NZ_CP096942:c196971-196690 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT198653 WP_003408528.1 NZ_CP072765:1969277-1969489 [Mycobacterium tuberculosis]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp

>AT198653 NZ_CP096942:c197195-196968 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TKL9

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References