Detailed information of TA system TA198646

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1384284..1384972
• Replicon: chromosome
• Accession: NZ_CP072765
• Organism: Mycobacterium tuberculosis strain H37Rv_CG

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: J8668_RS06505
• Protein ID: WP_003406304.1
• Coordinates: 1384541..1384972 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0THR6
• Locus tag: J8668_RS06500
• Protein ID: WP_003406302.1
• Coordinates: 1384284..1384544 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J8668_RS06480 (J8668_06480)	1379861..1380685	+	825	WP_003900298.1	trehalose ABC transporter permease SugB	-
J8668_RS06485 (J8668_06485)	1380690..1381871	+	1182	WP_003406299.1	trehalose ABC transporter ATP-binding protein SugC	-
J8668_RS06490 (J8668_06490)	1381948..1383048	-	1101	WP_003916789.1	magnesium/cobalt transporter CorA	-
J8668_RS06495 (J8668_06495)	1383219..1384208	+	990	WP_003406301.1	malate dehydrogenase	-
J8668_RS06500 (J8668_06500)	1384284..1384544	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
J8668_RS06505 (J8668_06505)	1384541..1384972	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
J8668_RS06510 (J8668_06510)	1384995..1386683	-	1689	WP_003910308.1	PE family protein	-
J8668_RS06515 (J8668_06515)	1386863..1387723	+	861	WP_003900301.1	glycine betaine ABC transporter substrate-binding protein	-
J8668_RS06520 (J8668_06520)	1387804..1388634	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
J8668_RS06525 (J8668_06525)	1388691..1388984	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	-
J8668_RS06530 (J8668_06530)	1388981..1389250	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T198646 WP_003406304.1 NZ_CP072765:1384541-1384972 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T198646 NZ_CP096939:c28956-28579 [Pseudomonas aeruginosa]
ATGACAAACAAAGAAAAACCGCTCGAATGGATCGCGAGCAGCCACAAGGATTTGATGGCGTTGCCGTCCGACGTGCGTCG
CCGTTTCGGTTACGCGCTCTCGTTGGCGCAGATAGGCGATCAGGATGACGCAGCAAAGGAGCTCAAGGGGTTCGGTGGTG
CCGGCGTGCTGGAGGTCGTCGAAGACGATGCCGGCGGCACCTATCGAGCGGTATACACGGTCAAGTTTGCGGAAGCGGTG
TTCGTCCTGCACTGCTTCCAGAAGAAGAGCAAGAGCGGAATCGCCACGCCAAAGGCCGACATGGACATCATCCGCGCTCG
GCTGAAGGTGGCCGAGGTATTGGCACAGGAGCTACGAAATGCAAAAACGAATCATTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9918.25 Da
• Isoelectric Point: 6.4755

>AT198646 WP_003406302.1 NZ_CP072765:1384284-1384544 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Nucleotide

• Length: 261 bp

>AT198646 NZ_CP096939:c28598-28263 [Pseudomonas aeruginosa]
ATGCAAAAACGAATCATTGAAGGCGTCGAGGTTCAGCGCAGCTCGGGCAACGTCTTTGCCGACCTTGGACTGCCTGACGC
TGAAAAGCTCAAGATCAAGACCGGCCTGGTGGTCGAGATCAGGAGGGCCATGCGCGCCCTTGGGCTGACTCAACAAGCGG
CGGCCAAACGCATGGGCATCCCGCAACCGAAGGTGTCGGGCATGATGCGCGGCGACTTCACCAATCTATCCGAACGCAAG
CTGATGGATTGTCTGAATCGCCTCGGCTACGACATCGAAATCAAGGTACGGCCAGCAGCCGAGCCGATCGGGCATCTAAC
GCTCGCAACCGCTTAA

Structures

Toxin

• AlphaFold DB: G0THR7

Antitoxin

• AlphaFold DB: G0THR6