Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 752987..753620 Replicon chromosome
Accession NZ_CP072765
Organism Mycobacterium tuberculosis strain H37Rv_CG

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag J8668_RS03440 Protein ID WP_003403365.1
Coordinates 752987..753370 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag J8668_RS03445 Protein ID WP_003403368.1
Coordinates 753465..753620 (-) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8668_RS03415 (J8668_03415) 748279..748815 + 537 WP_003403341.1 50S ribosomal protein L10 -
J8668_RS03420 (J8668_03420) 748852..749244 + 393 WP_003403353.1 50S ribosomal protein L7/L12 -
J8668_RS03425 (J8668_03425) 749237..749932 - 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
J8668_RS03430 (J8668_03430) 750003..751508 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
J8668_RS03435 (J8668_03435) 751589..752599 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
J8668_RS03440 (J8668_03440) 752987..753370 - 384 WP_003403365.1 ribonuclease VapC6 Toxin
J8668_RS03445 (J8668_03445) 753465..753620 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
J8668_RS03450 (J8668_03450) 753696..754412 - 717 WP_010886082.1 CPBP family intramembrane metalloprotease -
J8668_RS03455 (J8668_03455) 754688..754996 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
J8668_RS03460 (J8668_03460) 754983..755228 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
J8668_RS03465 (J8668_03465) 755338..755775 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
J8668_RS03470 (J8668_03470) 755772..756026 - 255 WP_003911263.1 antitoxin VapB7 -
J8668_RS03475 (J8668_03475) 756140..758503 + 2364 WP_003898547.1 arylsulfatase AtsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T198636 WP_003403365.1 NZ_CP072765:c753370-752987 [Mycobacterium tuberculosis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T198636 NZ_CP096934:c179604-179323 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGATAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT198636 WP_003403368.1 NZ_CP072765:c753620-753465 [Mycobacterium tuberculosis]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT198636 NZ_CP096934:c179828-179601 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSF8

References