Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 363826..364469 Replicon chromosome
Accession NZ_CP072765
Organism Mycobacterium tuberculosis strain H37Rv_CG

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB8
Locus tag J8668_RS01590 Protein ID WP_003401566.1
Coordinates 364044..364469 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag J8668_RS01585 Protein ID WP_003401563.1
Coordinates 363826..364047 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8668_RS01560 (J8668_01560) 358945..359748 - 804 WP_003401540.1 Stf0 family sulphotransferase -
J8668_RS01565 (J8668_01565) 359758..361155 - 1398 WP_003401544.1 sulfatase -
J8668_RS01570 (J8668_01570) 361334..363109 + 1776 WP_010886074.1 PE family protein -
J8668_RS01575 (J8668_01575) 363252..363479 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
J8668_RS01580 (J8668_01580) 363476..363778 + 303 WP_003401560.1 toxin-antitoxin system toxin -
J8668_RS01585 (J8668_01585) 363826..364047 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
J8668_RS01590 (J8668_01590) 364044..364469 + 426 WP_003401566.1 PIN domain nuclease Toxin
J8668_RS01595 (J8668_01595) 364605..365237 + 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
J8668_RS01600 (J8668_01600) 365234..366142 + 909 WP_003900117.1 protochlorophyllide reductase -
J8668_RS20555 366150..366740 - 591 WP_229298012.1 hypothetical protein -
J8668_RS20560 366733..366783 - 51 Protein_318 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15713.90 Da        Isoelectric Point: 5.6002

>T198626 WP_003401566.1 NZ_CP072765:364044-364469 [Mycobacterium tuberculosis]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA

Download         Length: 426 bp

>T198626 NZ_CP096929:c179592-179311 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGATAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT198626 WP_003401563.1 NZ_CP072765:363826-364047 [Mycobacterium tuberculosis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp

>AT198626 NZ_CP096929:c179816-179589 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3H87

Antitoxin

Source ID Structure
PDB 3H87
AlphaFold DB A0A829CG48

References