Detailed information of TA system TA198622

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-PHD
• Location: 3831324..3832009
• Replicon: chromosome
• Accession: NZ_CP072764
• Organism: Mycobacterium tuberculosis strain CG20

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: P9WF49
• Locus tag: J8671_RS17885
• Protein ID: WP_003917170.1
• Coordinates: 3831599..3832009 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: J8671_RS17880
• Protein ID: WP_003912220.1
• Coordinates: 3831324..3831602 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J8671_RS17860 (J8671_17860)	3827313..3828914	-	1602	WP_003417969.1	FAD/NAD(P)-binding protein	-
J8671_RS17865 (J8671_17865)	3828931..3829635	-	705	WP_003417980.1	dTDP-4-amino-4,6-dideoxyglucose formyltransferase	-
J8671_RS17870 (J8671_17870)	3829753..3830319	-	567	WP_003417984.1	TetR/AcrR family transcriptional regulator	-
J8671_RS17875 (J8671_17875)	3830381..3831268	+	888	WP_003900050.1	alpha-ketoglutarate-dependent sulfate ester dioxygenase	-
J8671_RS17880 (J8671_17880)	3831324..3831602	+	279	WP_003912220.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
J8671_RS17885 (J8671_17885)	3831599..3832009	+	411	WP_003917170.1	type II toxin-antitoxin system VapC family toxin	Toxin
J8671_RS17890 (J8671_17890)	3832042..3833778	-	1737	WP_003418002.1	cholesterol oxidase	-
J8671_RS17895 (J8671_17895)	3833834..3834961	-	1128	WP_003418005.1	GuaB3 family IMP dehydrogenase-related protein	-
J8671_RS17900 (J8671_17900)	3834981..3836570	-	1590	WP_003900682.1	IMP dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-118)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-54)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 14669.76 Da
• Isoelectric Point: 5.1784

>T198622 WP_003917170.1 NZ_CP072764:3831599-3832009 [Mycobacterium tuberculosis]
VIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVESMRVVARYGQPGQTERARYLLDGLDILPLTEPVIG
LAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Nucleotide

• Length: 411 bp

>T198622 NZ_CP096927:c5096347-5096057 [Pseudomonas aeruginosa]
ATGACCGAGCAAATTTATGATTATGACCCCGCGCAAGCGCTGGATAGCCCGGAGGCCATGGCTCTGTTCATCGCAGACGC
TTTGGATACTGGAGACACCGCCTATATCGCTAAGGCTATGGGAGTCGTGGCCCGCGCCAAGGGGATGACGGAGTTGGCCA
AGGAAACGGGTTTGGCCAGGGAGCAGCTTTACAAATCGTTTAGTGAGCGCGGGAACCCTACATTGAAAACCATGCTGGCA
GTAATGCGAGCTCTGGGAGTTGATCTGACCGCCCGCCCGCATGCTCAGTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10280.75 Da
• Isoelectric Point: 10.1819

>AT198622 WP_003912220.1 NZ_CP072764:3831324-3831602 [Mycobacterium tuberculosis]
VEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEPARGRKRT
LSDVLNEMRDEQ

Nucleotide

• Length: 279 bp

>AT198622 NZ_CP096927:c5096643-5096344 [Pseudomonas aeruginosa]
ATGGTTGAAGTCAAACAAACCGCCACTTTCATGGCATGGGAAAGCAAGCTAAAGGATCGGCGGGCAAAGGCCGTGATCGC
CGCCCGTATCTTCCGATTGGCGAATGGACTACCCGGCGATGTGTCACCAGTCGGCCAGGGTGTGAGCGAGTTGAGGATTC
ACTATGGCCCAGGCTATCGGGTGTACTTCCAGCAGCGCGGGACGGAAATCGTCATCCTGCTATGTGGTGGAGACAAGAGC
AGCCAGGCCAGGGATATAGAAATGGCGAAACGCCTGGCAAATGAGTGGAGGCCGCAATGA

Structures

Toxin

• AlphaFold DB: A5U883