Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | abiEi-abiEii/AbiEii-AbiEi |
| Location | 3138705..3140479 | Replicon | chromosome |
| Accession | NZ_CP072764 | ||
| Organism | Mycobacterium tuberculosis strain CG20 | ||
Toxin (Protein)
| Gene name | abiEi | Uniprot ID | P71626 |
| Locus tag | J8671_RS14830 | Protein ID | WP_003414409.1 |
| Coordinates | 3138705..3139589 (-) | Length | 295 a.a. |
Antitoxin (Protein)
| Gene name | abiEii | Uniprot ID | P71625 |
| Locus tag | J8671_RS14835 | Protein ID | WP_003414414.1 |
| Coordinates | 3139592..3140479 (-) | Length | 296 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J8671_RS14810 (J8671_14810) | 3133969..3134343 | - | 375 | WP_003414296.1 | type III-A CRISPR-associated protein Csm2 | - |
| J8671_RS14815 (J8671_14815) | 3134340..3136769 | - | 2430 | WP_003911999.1 | type III-A CRISPR-associated protein Cas10/Csm1 | - |
| J8671_RS14820 (J8671_14820) | 3136766..3137554 | - | 789 | WP_003917092.1 | CRISPR-associated endoribonuclease Cas6 | - |
| J8671_RS14825 (J8671_14825) | 3137888..3138433 | - | 546 | WP_003913758.1 | DUF1802 family protein | - |
| J8671_RS14830 (J8671_14830) | 3138705..3139589 | - | 885 | WP_003414409.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| J8671_RS14835 (J8671_14835) | 3139592..3140479 | - | 888 | WP_003414414.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| J8671_RS14840 (J8671_14840) | 3140784..3141329 | - | 546 | WP_003899500.1 | DUF1802 family protein | - |
| J8671_RS14845 (J8671_14845) | 3141326..3141595 | - | 270 | WP_003414489.1 | DUF2277 family protein | - |
| J8671_RS14850 (J8671_14850) | 3141616..3142008 | - | 393 | WP_003414492.1 | type II toxin-antitoxin system VapC family toxin | - |
| J8671_RS14855 (J8671_14855) | 3142005..3142220 | - | 216 | WP_003912003.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| J8671_RS14860 (J8671_14860) | 3142267..3143016 | + | 750 | WP_003414497.1 | enoyl-CoA hydratase | - |
| J8671_RS14865 (J8671_14865) | 3143095..3144177 | - | 1083 | WP_003414499.1 | sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 295 a.a. Molecular weight: 33056.72 Da Isoelectric Point: 7.1520
>T198614 WP_003414409.1 NZ_CP072764:c3139589-3138705 [Mycobacterium tuberculosis]
VAGLTRALVARHALGRAEAYDAALLDVAQDHLLYLLSQTVQFGDNRLVFKGGTSLRKCRLGNVGRFSTDLDFSAPDDEVV
LEVCELIDGARVGGFEFGVQSTRGDGRHWQLRVRHTELGEPRIVASVEFARRPLALPSELLAFIQLPIHKAYGFGLPTLP
VVAEAEACAEKLARYRRVALARDLYDLNHFASRTIDEPLVRRLWVLKVWGDVVDDRRGTRPLRVEDVLAARSEHDFQPDS
IGVLTRPVAMAAWEARVRKRFAFLTDLDADEQRWAACDERHRREVENALAVLRS
VAGLTRALVARHALGRAEAYDAALLDVAQDHLLYLLSQTVQFGDNRLVFKGGTSLRKCRLGNVGRFSTDLDFSAPDDEVV
LEVCELIDGARVGGFEFGVQSTRGDGRHWQLRVRHTELGEPRIVASVEFARRPLALPSELLAFIQLPIHKAYGFGLPTLP
VVAEAEACAEKLARYRRVALARDLYDLNHFASRTIDEPLVRRLWVLKVWGDVVDDRRGTRPLRVEDVLAARSEHDFQPDS
IGVLTRPVAMAAWEARVRKRFAFLTDLDADEQRWAACDERHRREVENALAVLRS
Download Length: 885 bp
>T198614 NZ_CP096923:c2218584-2218399 [Enterobacter hormaechei]
GTGAAAAGTGCGGATATCATTGCTGTTCTGGTTAGCCATGGCTGGAAATGTGTAAGAACGAAGGGAAGCCATCATCAGTT
TCGCCATCCAGTGCAAAAAGGGTTGGTAACCGTTCCGCATCCTAAAAAGGACATTAAACCGGGCACTCTCGCGCAGATCT
GGCGACAGGCGGGCATTAAACACTGA
GTGAAAAGTGCGGATATCATTGCTGTTCTGGTTAGCCATGGCTGGAAATGTGTAAGAACGAAGGGAAGCCATCATCAGTT
TCGCCATCCAGTGCAAAAAGGGTTGGTAACCGTTCCGCATCCTAAAAAGGACATTAAACCGGGCACTCTCGCGCAGATCT
GGCGACAGGCGGGCATTAAACACTGA
Antitoxin
Download Length: 296 a.a. Molecular weight: 32315.19 Da Isoelectric Point: 9.4723
>AT198614 WP_003414414.1 NZ_CP072764:c3140479-3139592 [Mycobacterium tuberculosis]
VVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAI
SDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPAL
LVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGE
PARGQALLAKRHTEVMPVTRFTTAHSRDRGESVWAPEYQLVDELVVPLLRVIGKA
VVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAI
SDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPAL
LVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGE
PARGQALLAKRHTEVMPVTRFTTAHSRDRGESVWAPEYQLVDELVVPLLRVIGKA
Download Length: 888 bp
>AT198614 NZ_CP096923:c2218384-2217977 [Enterobacter hormaechei]
ATGTTTTATCCGGCTTACATTCATTCTGATTCCGATGGTAGCGCCAGCGGTTTCTTCCCTGACGTTCCGGGATGTTTTTT
TGCGGGAGATTCACTTGATGATGCTTTTCAGGATGCACGTGAAGCGCTCACAGCGCACTTCGAAGCGCTGTTTGAAATGG
ATGAGGCATTGCCTCTCCCGGGTAATGTCGAAGTGCACCTTGAAAATCATCCTGACGACTTCTCAGGCGGGCAATGGTTG
CTGGTGGATATAAATATGAAGCAGTTCGACGGCAGAGCCGAACGCATCAACATCACGATGCCTCGACGGTTGCTGGTGAA
GATTGATTCCTTTGTCAGCGAGCATCCTCAATTCGGCAATCGAAGCGCATTTCTGGCCGAGGCAGCACGTCGCGTGCTGC
CTCGGTGA
ATGTTTTATCCGGCTTACATTCATTCTGATTCCGATGGTAGCGCCAGCGGTTTCTTCCCTGACGTTCCGGGATGTTTTTT
TGCGGGAGATTCACTTGATGATGCTTTTCAGGATGCACGTGAAGCGCTCACAGCGCACTTCGAAGCGCTGTTTGAAATGG
ATGAGGCATTGCCTCTCCCGGGTAATGTCGAAGTGCACCTTGAAAATCATCCTGACGACTTCTCAGGCGGGCAATGGTTG
CTGGTGGATATAAATATGAAGCAGTTCGACGGCAGAGCCGAACGCATCAACATCACGATGCCTCGACGGTTGCTGGTGAA
GATTGATTCCTTTGTCAGCGAGCATCCTCAATTCGGCAATCGAAGCGCATTTCTGGCCGAGGCAGCACGTCGCGTGCTGC
CTCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|