Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2813079..2813731 Replicon chromosome
Accession NZ_CP072764
Organism Mycobacterium tuberculosis strain CG20

Toxin (Protein)


Gene name vapC Uniprot ID G0TPX1
Locus tag J8671_RS13100 Protein ID WP_003412752.1
Coordinates 2813306..2813731 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag J8671_RS13095 Protein ID WP_003412749.1
Coordinates 2813079..2813300 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8671_RS13080 (J8671_13080) 2811319..2811525 - 207 WP_003899347.1 hypothetical protein -
J8671_RS13085 (J8671_13085) 2811661..2812284 + 624 WP_003900858.1 TIGR00725 family protein -
J8671_RS13090 (J8671_13090) 2812274..2813026 + 753 WP_003900859.1 hypothetical protein -
J8671_RS13095 (J8671_13095) 2813079..2813300 + 222 WP_003412749.1 antitoxin Antitoxin
J8671_RS13100 (J8671_13100) 2813306..2813731 + 426 WP_003412752.1 type II toxin-antitoxin system VapC family toxin Toxin
J8671_RS13105 (J8671_13105) 2813754..2814935 - 1182 WP_003899351.1 dihydrolipoamide acetyltransferase family protein -
J8671_RS13110 (J8671_13110) 2814932..2815978 - 1047 WP_003412757.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
J8671_RS13115 (J8671_13115) 2815989..2817092 - 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
J8671_RS13120 (J8671_13120) 2817351..2818172 - 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
J8671_RS13125 (J8671_13125) 2818169..2818726 - 558 WP_003412768.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15392.89 Da        Isoelectric Point: 9.2386

>T198604 WP_003412752.1 NZ_CP072764:2813306-2813731 [Mycobacterium tuberculosis]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

>T198604 NZ_CP096917:3510-3788 [Alcaligenes faecalis]
ATGATTCATTCGTTCACTTGTCTCGATACCGAGGCGCTTTTCCGTAGCCAGGTCGTGCCTCGGTTCAAGAACATTGAACG
TGTGGCGCGGCGAAAGCTCTTGCAAATACATGCCGCCACTGAATTGGCCAGCTTGAGGGTTCCACCTGGGAACCAGCTTG
AGGCATTAAAGGGCGACCGCCGAGGGCAACACAGTATCCGCATCAATGACCAGTGGCGAATCTGCTTCGTATGGCATGAC
GACGGTGCCCACCAGGTCGAAATTGTGGACTACCACTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT198604 WP_003412749.1 NZ_CP072764:2813079-2813300 [Mycobacterium tuberculosis]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp

>AT198604 NZ_CP096917:3798-4106 [Alcaligenes faecalis]
ATGGCTGAACTACTTGACGAAATCCACCCCGGCGAAATCTTGCTGGAGGACTTCATGAAGCCGATGGGAATATCCGCCCG
TCAGCTTGCGGCTGACATTGATGTTTCACCCAGCCGGATCAGTGATCTGGTGCATGGGAATCGTCCGATTACCGCCGACA
CGGCTTTGCGGCTTGGCTTGTTTTTCAACATGGAACCGCGTTTCTGGATGAACCTGCAAACCGAGTACGACATGCGCGTT
GCGGCCCGTACCGTGCGTGAAAAAATCGCGCCAAGGATTCGTGTTTTCCATCATCACGCTGCTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPX1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References