Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2405123..2405652 Replicon chromosome
Accession NZ_CP072764
Organism Mycobacterium tuberculosis strain CG20

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag J8671_RS11195 Protein ID WP_003411124.1
Coordinates 2405123..2405440 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag J8671_RS11200 Protein ID WP_003411127.1
Coordinates 2405437..2405652 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8671_RS11165 (J8671_11165) 2400260..2401336 + 1077 WP_003411110.1 hypothetical protein -
J8671_RS11170 (J8671_11170) 2401333..2401614 + 282 WP_003411112.1 DUF5703 family protein -
J8671_RS11175 (J8671_11175) 2401650..2402723 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
J8671_RS11180 (J8671_11180) 2402728..2403258 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
J8671_RS11185 (J8671_11185) 2403306..2404652 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
J8671_RS11195 (J8671_11195) 2405123..2405440 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J8671_RS11200 (J8671_11200) 2405437..2405652 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
J8671_RS11205 (J8671_11205) 2405907..2406965 + 1059 WP_003411129.1 phosphoribosyltransferase family protein -
J8671_RS11210 (J8671_11210) 2407095..2407451 - 357 WP_003411130.1 hypothetical protein -
J8671_RS11215 (J8671_11215) 2407546..2408328 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
J8671_RS11220 (J8671_11220) 2408596..2408886 - 291 WP_003900476.1 YggT family protein -
J8671_RS11225 (J8671_11225) 2409048..2409704 - 657 WP_003411133.1 cell division protein SepF -
J8671_RS11230 (J8671_11230) 2409770..2410546 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T198603 WP_003411124.1 NZ_CP072764:c2405440-2405123 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T198603 NZ_CP096916:c2375664-2375338 [Alcaligenes faecalis]
ATGAGGCGTGGGGATCTAGTTACTGTTGCAATGCAAGGGGATTTTGGTAAACCTCGGCCTGCGTTAGTGATCCAGGCGGA
TTTATTTGCTGCCCATTCCTCTGTCACAGTACTCCCAGTAACCAGCACAATTGTGAATGCGCCTTTATTGCGCATTAGCA
TTCAGCCAGACCTAGAGAATGGTCTACAAAAACCATCACAAATCATGATCGATAAGGCATTGACCGTTAAACGGGATAAG
ATTGGCCAAGCCTTTGGATCTGTTAGTGCTGATACACTGGTGGAAATTGAACGATCCTTGGCTGTATTTTTGGGTATTGC
GAAGTAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT198603 WP_003411127.1 NZ_CP072764:c2405652-2405437 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT198603 NZ_CP096916:c2375891-2375661 [Alcaligenes faecalis]
ATGGAGATCAAGATGGCAAATGTAAACGCAAGAGTTCAGAAGCACCGTGATTCACTCCGGCAAGCAGGATTGCGTCCAGT
GCAGCTTTGGGTGCCTGATACACGTCGGCCTGATTTTGCGGCTGAATGCCGTCGTCAGGCGCTGCGGGTGGCCAAGGCAG
ATAAGGCTGATGTGGATACAGAGCATTTTATGGATGAGGCTCTGGCTGACCTGGATGGTTGGACAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References