198559

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3775816..3776345 Replicon chromosome
Accession NZ_CP072763
Organism Mycobacterium tuberculosis strain CG21

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag J8666_RS17640 Protein ID WP_003417760.1
Coordinates 3776088..3776345 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag J8666_RS17635 Protein ID WP_003417757.1
Coordinates 3775816..3776091 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8666_RS20955 3772389..3773078 - 690 WP_003917774.1 BBE domain-containing protein -
J8666_RS20960 3773265..3773636 - 372 WP_003417739.1 FAD-binding protein -
J8666_RS20965 3773534..3773752 - 219 WP_157132559.1 hypothetical protein -
J8666_RS20970 3773779..3774039 - 261 WP_003417741.1 hypothetical protein -
J8666_RS17620 (J8666_17620) 3774154..3774543 + 390 WP_003417745.1 DUF732 domain-containing protein -
J8666_RS17625 (J8666_17625) 3774557..3774850 - 294 WP_003417749.1 DUF3017 domain-containing protein -
J8666_RS17630 (J8666_17630) 3774847..3775692 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
J8666_RS17635 (J8666_17635) 3775816..3776091 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
J8666_RS17640 (J8666_17640) 3776088..3776345 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
J8666_RS17645 (J8666_17645) 3776387..3777577 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
J8666_RS17650 (J8666_17650) 3777694..3778062 + 369 WP_003417765.1 FHA domain-containing protein -
J8666_RS17655 (J8666_17655) 3778059..3778610 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
J8666_RS17660 (J8666_17660) 3778617..3779198 - 582 WP_003417769.1 ATP/GTP-binding protein -
J8666_RS17665 (J8666_17665) 3779179..3779547 - 369 WP_003417772.1 DUF742 domain-containing protein -
J8666_RS17670 (J8666_17670) 3779525..3779917 - 393 WP_003417776.1 serine protease inhibitor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T198559 WP_003417760.1 NZ_CP072763:3776088-3776345 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T198559 NZ_CP096902:2778100-2778207 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT198559 WP_003417757.1 NZ_CP072763:3775816-3776091 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT198559 NZ_CP096902:c2778050-2777987 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
AlphaFold DB G0TI94

References