Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/PIN(toxin) |
| Location | 2874724..2875361 | Replicon | chromosome |
| Accession | NZ_CP072763 | ||
| Organism | Mycobacterium tuberculosis strain CG21 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | P0DMV7 |
| Locus tag | J8666_RS13400 | Protein ID | WP_003413180.1 |
| Coordinates | 2874724..2875119 (-) | Length | 132 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | P9WJ44 |
| Locus tag | J8666_RS13405 | Protein ID | WP_003413183.1 |
| Coordinates | 2875116..2875361 (-) | Length | 82 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J8666_RS13360 (J8666_13360) | 2870127..2871338 | + | 1212 | WP_009936235.1 | alpha/beta hydrolase family protein | - |
| J8666_RS13365 (J8666_13365) | 2871465..2872124 | + | 660 | WP_003900846.1 | LppA family lipoprotein | - |
| J8666_RS13370 (J8666_13370) | 2872121..2872783 | + | 663 | WP_003900848.1 | LppA family lipoprotein | - |
| J8666_RS13375 (J8666_13375) | 2872780..2873058 | + | 279 | WP_003901422.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| J8666_RS13380 (J8666_13380) | 2873151..2873564 | + | 414 | WP_003413164.1 | PIN domain nuclease | - |
| J8666_RS13385 (J8666_13385) | 2873603..2873860 | + | 258 | WP_003413167.1 | CopG family transcriptional regulator | - |
| J8666_RS13390 (J8666_13390) | 2873857..2874234 | + | 378 | WP_003413174.1 | type II toxin-antitoxin system VapC family toxin | - |
| J8666_RS13395 (J8666_13395) | 2874250..2874624 | - | 375 | WP_003413177.1 | hypothetical protein | - |
| J8666_RS13400 (J8666_13400) | 2874724..2875119 | - | 396 | WP_003413180.1 | type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 | Toxin |
| J8666_RS13405 (J8666_13405) | 2875116..2875361 | - | 246 | WP_003413183.1 | type II toxin-antitoxin system antitoxin VapB20 | Antitoxin |
| J8666_RS13410 (J8666_13410) | 2875772..2876191 | - | 420 | WP_003413190.1 | A24 family peptidase | - |
| J8666_RS13415 (J8666_13415) | 2876203..2877012 | - | 810 | WP_003413193.1 | shikimate dehydrogenase | - |
| J8666_RS13420 (J8666_13420) | 2877009..2878262 | - | 1254 | WP_003413196.1 | endolytic transglycosylase MltG | - |
| J8666_RS13425 (J8666_13425) | 2878255..2878767 | - | 513 | WP_003413197.1 | Holliday junction resolvase RuvX | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 132 a.a. Molecular weight: 14619.53 Da Isoelectric Point: 6.9794
>T198547 WP_003413180.1 NZ_CP072763:c2875119-2874724 [Mycobacterium tuberculosis]
MIFVDTSFWAALGNAGDARHGTAKRLWASKPPVVMTSNHVLGETWTLLNRRCGHRAAVAAAAIRLSTVVRVEHVTADLEE
QAWEWLVRHDEREYSFVDATSFAVMRKKGIQNAYAFDGDFSAAGFVEVRPE
MIFVDTSFWAALGNAGDARHGTAKRLWASKPPVVMTSNHVLGETWTLLNRRCGHRAAVAAAAIRLSTVVRVEHVTADLEE
QAWEWLVRHDEREYSFVDATSFAVMRKKGIQNAYAFDGDFSAAGFVEVRPE
Download Length: 396 bp
>T198547 NZ_CP096902:c594943-594479 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTTTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTTTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA
Antitoxin
Download Length: 82 a.a. Molecular weight: 9098.33 Da Isoelectric Point: 5.6007
>AT198547 WP_003413183.1 NZ_CP072763:c2875361-2875116 [Mycobacterium tuberculosis]
MLVAYICHVKRLQIYIDEDVDRALAVEARRRRTSKAALIREYVAEHLRQPGPDPVDAFVGSFVGEADLSASVDDVVYGKH
E
MLVAYICHVKRLQIYIDEDVDRALAVEARRRRTSKAALIREYVAEHLRQPGPDPVDAFVGSFVGEADLSASVDDVVYGKH
E
Download Length: 246 bp
>AT198547 NZ_CP096902:c595278-594943 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 5WZ4 | |
| PDB | 5WZF |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BW31 |