Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2235670..2236568 Replicon chromosome
Accession NZ_CP072763
Organism Mycobacterium tuberculosis strain CG21

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag J8666_RS10400 Protein ID WP_003410001.1
Coordinates 2235670..2236230 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag J8666_RS10405 Protein ID WP_003410003.1
Coordinates 2236227..2236568 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T198536 WP_003410001.1 NZ_CP072763:c2236230-2235670 [Mycobacterium tuberculosis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T198536 NZ_CP096882:1276815-1277066 [Pseudarthrobacter sp. SSS035]
GTGAAAACACTTACCTACTCCCAGTCGCGCGCGCACTACAAGGAAACTCTCGACGCCGTCACGGACGACCGCGAAGAAGT
GATCATCACGCGCCCCGGCAAGGAAGACGTGGTCATCGTCTCGCGGGCCGATTACGAATCCCTTCGCGAAACGGCTTATC
TGCTCCGGAGCCCAGCCAATGCCCGGCGCATTCTGGAATCCATCGAGCGCCTCGAATCCGGGCACGGGACCGAACGCGAT
CTTCTTGAATGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT198536 WP_003410003.1 NZ_CP072763:c2236568-2236227 [Mycobacterium tuberculosis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT198536 NZ_CP096882:1277063-1277335 [Pseudarthrobacter sp. SSS035]
ATGAAGCACTCGTGGGACGAAAGTGCCTGGGAGGACTACCTGTGGTGGCAGGCCCAGGACCGCAGGACAATGAAGCGGAT
CAAAACTCTGATTCAAGACATCGCCCGAAACGGCAACGAAGGCATCGGAAAACCCGAGCCGCTCAAGCACGGCTTTCACG
GCTATTGGTCACGCCGCATCACTGACGAGCACCGACTCGTCTACCGCTACGTGGAAAGTGGCTCCGGCGTCGAAATCCTG
ATTGCCGCCTGCCGGTACCACTACGGCAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References