Detailed information of TA system TA198505

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 444223..445234
• Replicon: chromosome
• Accession: NZ_CP072763
• Organism: Mycobacterium tuberculosis strain CG21

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: L7N5R2
• Locus tag: J8666_RS01915
• Protein ID: WP_003401859.1
• Coordinates: 444223..444816 (-)
• Length: 198 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: O53702
• Locus tag: J8666_RS01920
• Protein ID: WP_003401860.1
• Coordinates: 444845..445234 (-)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J8666_RS01895 (J8666_01895)	439872..441254	+	1383	WP_003898415.1	magnesium transporter	-
J8666_RS01900 (J8666_01900)	441266..442300	-	1035	WP_003401856.1	class II fructose-bisphosphate aldolase	-
J8666_RS01905 (J8666_01905)	442396..443079	+	684	WP_003401857.1	VTT domain-containing protein	-
J8666_RS01910 (J8666_01910)	443068..444198	-	1131	WP_003401858.1	glycoside hydrolase family 76 protein	-
J8666_RS01915 (J8666_01915)	444223..444816	-	594	WP_003401859.1	zeta toxin family protein	Toxin
J8666_RS01920 (J8666_01920)	444845..445234	-	390	WP_003401860.1	hypothetical protein	Antitoxin
J8666_RS01925 (J8666_01925)	445315..446526	-	1212	WP_003906353.1	VWA domain-containing protein	-
J8666_RS01930 (J8666_01930)	446532..447134	-	603	WP_003898417.1	SRPBCC family protein	-
J8666_RS01935 (J8666_01935)	447148..448044	-	897	WP_003898418.1	MoxR family ATPase	-
J8666_RS01940 (J8666_01940)	448041..448634	-	594	WP_003401864.1	NTP transferase domain-containing protein	-
J8666_RS01945 (J8666_01945)	448631..449386	-	756	WP_003401865.1	XdhC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (4-156)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 198 a.a.
• Molecular weight: 21344.53 Da
• Isoelectric Point: 10.5018

>T198505 WP_003401859.1 NZ_CP072763:c444816-444223 [Mycobacterium tuberculosis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Nucleotide

• Length: 594 bp

>T198505 NZ_CP096848:c1923553-1923164 [Mycobacterium tuberculosis variant bovis]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 13648.21 Da
• Isoelectric Point: 6.0829

>AT198505 WP_003401860.1 NZ_CP072763:c445234-444845 [Mycobacterium tuberculosis]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Nucleotide

• Length: 390 bp

>AT198505 NZ_CP096848:c1923777-1923550 [Mycobacterium tuberculosis variant bovis]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA

Structures

Toxin

• AlphaFold DB: A0A7U4BRU8

Antitoxin

• AlphaFold DB: A0A7U4BRT0