Detailed information of TA system TA198498

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Txe-YefM
• Location: 3792330..3792859
• Replicon: chromosome
• Accession: NZ_CP072762
• Organism: Mycobacterium tuberculosis strain CG23

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G0TI95
• Locus tag: J8672_RS17805
• Protein ID: WP_003417760.1
• Coordinates: 3792602..3792859 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G0TI94
• Locus tag: J8672_RS17800
• Protein ID: WP_003417757.1
• Coordinates: 3792330..3792605 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J8672_RS21125	3788903..3789592	-	690	WP_003917774.1	BBE domain-containing protein	-
J8672_RS21130	3789779..3790150	-	372	WP_003417739.1	FAD-binding protein	-
J8672_RS21135	3790048..3790266	-	219	WP_157132559.1	hypothetical protein	-
J8672_RS21140	3790293..3790553	-	261	WP_003417741.1	hypothetical protein	-
J8672_RS17785 (J8672_17785)	3790668..3791057	+	390	WP_003417745.1	DUF732 domain-containing protein	-
J8672_RS17790 (J8672_17790)	3791071..3791364	-	294	WP_003417749.1	DUF3017 domain-containing protein	-
J8672_RS17795 (J8672_17795)	3791361..3792206	-	846	WP_003417751.1	bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase	-
J8672_RS17800 (J8672_17800)	3792330..3792605	+	276	WP_003417757.1	type II toxin-antitoxin system antitoxin RelJ	Antitoxin
J8672_RS17805 (J8672_17805)	3792602..3792859	+	258	WP_003417760.1	Txe/YoeB family addiction module toxin	Toxin
J8672_RS17810 (J8672_17810)	3792901..3794091	+	1191	WP_003900033.1	NADH:flavin oxidoreductase	-
J8672_RS17815 (J8672_17815)	3794208..3794576	+	369	WP_003417765.1	FHA domain-containing protein	-
J8672_RS17820 (J8672_17820)	3794573..3795124	-	552	WP_003417767.1	pentapeptide repeat protein MfpA	-
J8672_RS17825 (J8672_17825)	3795131..3795712	-	582	WP_003417769.1	ATP/GTP-binding protein	-
J8672_RS17830 (J8672_17830)	3795693..3796061	-	369	WP_003417772.1	DUF742 domain-containing protein	-
J8672_RS17835 (J8672_17835)	3796039..3796431	-	393	WP_003417776.1	serine protease inhibitor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-72)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10070.30 Da
• Isoelectric Point: 6.4693

>T198498 WP_003417760.1 NZ_CP072762:3792602-3792859 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Nucleotide

• Length: 258 bp

>T198498 NZ_CP096848:1242816-1243190 [Mycobacterium tuberculosis variant bovis]
GTGATCCTGGTCGACACTTCGGTATGGATTGAGCACCTGCGCGCCGCCGACGCGCGACTCGTCGAGCTGCTGGGCGATGA
CGAGGCCGGTTGCCATCCGCTCGTCATCGAGGAGCTGGCGCTTGGCTCGATCAAGCAGCGAGACGTTGTTCTCGATCTGT
TGGCCAACCTCTACCAGTTTCCGGTGGTGACCCACGACGAAGTGTTGCGGCTTGTCGGTCGGCGGCGGTTGTGGGGTCGG
GGACTCGGTGCCGTCGATGCCAACCTTCTTGGTTCGGTGGCTCTGGTTGGCGGCGCGCGACTATGGACGCGGGACAAGCG
GTTGAAGGCGGCGTGCGCGGAAAGCGGTGTTGCGCTGGCTGAGGAAGTGTCCTGA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10194.35 Da
• Isoelectric Point: 4.6652

>AT198498 WP_003417757.1 NZ_CP072762:3792330-3792605 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Nucleotide

• Length: 276 bp

>AT198498 NZ_CP096848:1242622-1242819 [Mycobacterium tuberculosis variant bovis]
ATGAGGACGACGGTGACCGTTGACGACGCCTTGTTAGCCAAAGCGGCCGAATTGACTGGGGTGAAAGAGAAGTCGACGCT
CCTGCGCGAGGGGTTGCAGACACTGGTCCGGGTGGAGAGCGCCCGGCGGTTGGCGGCTCTCGGCGGCACCGACCCGCAAG
CTACCGCGGCGCCGAGACGCCGGACGTCGCCCCGGTGA

Structures

Toxin

• PDB: 3OEI

Antitoxin

• AlphaFold DB: G0TI94