Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-VapB |
| Location | 3092094..3092781 | Replicon | chromosome |
| Accession | NZ_CP072762 | ||
| Organism | Mycobacterium tuberculosis strain CG23 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | G0TF65 |
| Locus tag | J8672_RS14665 | Protein ID | WP_003414064.1 |
| Coordinates | 3092386..3092781 (-) | Length | 132 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | G0TF64 |
| Locus tag | J8672_RS14660 | Protein ID | WP_003414061.1 |
| Coordinates | 3092094..3092360 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J8672_RS14635 (J8672_14635) | 3087733..3088635 | - | 903 | WP_003900564.1 | 4-hydroxy-tetrahydrodipicolinate synthase | - |
| J8672_RS14640 (J8672_14640) | 3088704..3089456 | - | 753 | WP_003899465.1 | FAD-dependent thymidylate synthase | - |
| J8672_RS21045 | 3089483..3089620 | - | 138 | Protein_2925 | type II toxin-antitoxin system VapC family toxin | - |
| J8672_RS14645 (J8672_14645) | 3089700..3089975 | - | 276 | WP_003414055.1 | type I restriction endonuclease subunit S | - |
| J8672_RS14650 (J8672_14650) | 3089972..3091594 | - | 1623 | WP_003906897.1 | class I SAM-dependent DNA methyltransferase | - |
| J8672_RS14655 (J8672_14655) | 3091681..3092097 | - | 417 | WP_003414059.1 | type II toxin-antitoxin system toxin ribonuclease C21 | - |
| J8672_RS14660 (J8672_14660) | 3092094..3092360 | - | 267 | WP_003414061.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| J8672_RS14665 (J8672_14665) | 3092386..3092781 | - | 396 | WP_003414064.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| J8672_RS14670 (J8672_14670) | 3092778..3093047 | - | 270 | WP_003414066.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| J8672_RS14675 (J8672_14675) | 3093057..3094151 | - | 1095 | WP_003414068.1 | restriction endonuclease subunit S | - |
| J8672_RS14680 (J8672_14680) | 3094148..3094567 | - | 420 | WP_003414070.1 | winged helix-turn-helix domain-containing protein | - |
| J8672_RS21050 | 3094566..3094640 | + | 75 | Protein_2934 | hypothetical protein | - |
| J8672_RS14685 (J8672_14685) | 3094641..3095120 | - | 480 | WP_003414073.1 | dihydrofolate reductase | - |
| J8672_RS14690 (J8672_14690) | 3095191..3095991 | - | 801 | WP_003911953.1 | thymidylate synthase | - |
| J8672_RS14695 (J8672_14695) | 3096147..3096884 | + | 738 | WP_003414079.1 | dienelactone hydrolase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 132 a.a. Molecular weight: 14340.04 Da Isoelectric Point: 4.7145
>T198490 WP_003414064.1 NZ_CP072762:c3092781-3092386 [Mycobacterium tuberculosis]
VIVDTSAIVAIVSGESGAQVLKEALERSPNSRMSAPNYVELCAIMQRRDRPEISRLVDRLLDDYGIQVEAVDADQARVAA
QAYRDYGRGSGHPARLNLGDTYSYALAQVTGEPLLFRGDDFTHTDIRPACT
VIVDTSAIVAIVSGESGAQVLKEALERSPNSRMSAPNYVELCAIMQRRDRPEISRLVDRLLDDYGIQVEAVDADQARVAA
QAYRDYGRGSGHPARLNLGDTYSYALAQVTGEPLLFRGDDFTHTDIRPACT
Download Length: 396 bp
>T198490 NZ_CP096848:c756277-755894 [Mycobacterium tuberculosis variant bovis]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG
Antitoxin
Download Length: 89 a.a. Molecular weight: 9493.77 Da Isoelectric Point: 7.2783
>AT198490 WP_003414061.1 NZ_CP072762:c3092360-3092094 [Mycobacterium tuberculosis]
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA
Download Length: 267 bp
>AT198490 NZ_CP096848:c756527-756372 [Mycobacterium tuberculosis variant bovis]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|