Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/PIN(toxin) |
| Location | 2951581..2952295 | Replicon | chromosome |
| Accession | NZ_CP072762 | ||
| Organism | Mycobacterium tuberculosis strain CG23 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | G0TQK0 |
| Locus tag | J8672_RS13830 | Protein ID | WP_003413460.1 |
| Coordinates | 2951855..2952295 (+) | Length | 147 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | P9WJ20 |
| Locus tag | J8672_RS13825 | Protein ID | WP_003413456.1 |
| Coordinates | 2951581..2951868 (+) | Length | 96 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J8672_RS13790 (J8672_13790) | 2947003..2947248 | + | 246 | WP_003413429.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| J8672_RS13795 (J8672_13795) | 2947245..2947649 | + | 405 | WP_003899389.1 | type II toxin-antitoxin system VapC family toxin | - |
| J8672_RS13800 (J8672_13800) | 2947866..2948486 | + | 621 | WP_003413441.1 | DUF4178 domain-containing protein | - |
| J8672_RS13805 (J8672_13805) | 2948497..2948991 | + | 495 | WP_003413444.1 | DUF2617 family protein | - |
| J8672_RS13810 (J8672_13810) | 2948988..2949419 | + | 432 | WP_003899390.1 | DUF4247 domain-containing protein | - |
| J8672_RS13815 (J8672_13815) | 2949474..2949902 | + | 429 | WP_178121172.1 | DUF350 domain-containing protein | - |
| J8672_RS13820 (J8672_13820) | 2949899..2951470 | + | 1572 | WP_003899392.1 | polyamine aminopropyltransferase | - |
| J8672_RS13825 (J8672_13825) | 2951581..2951868 | + | 288 | WP_003413456.1 | antitoxin VapB41 | Antitoxin |
| J8672_RS13830 (J8672_13830) | 2951855..2952295 | + | 441 | WP_003413460.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| J8672_RS13835 (J8672_13835) | 2952316..2953071 | - | 756 | WP_003413464.1 | YebC/PmpR family DNA-binding transcriptional regulator | - |
| J8672_RS13840 (J8672_13840) | 2953204..2953800 | - | 597 | WP_003413465.1 | pyridoxal 5'-phosphate synthase glutaminase subunit PdxT | - |
| J8672_RS13845 (J8672_13845) | 2953808..2954653 | - | 846 | WP_003413466.1 | acyl-CoA thioesterase II | - |
| J8672_RS13850 (J8672_13850) | 2954682..2955581 | - | 900 | WP_003413468.1 | pyridoxal 5'-phosphate synthase lyase subunit PdxS | - |
| J8672_RS13855 (J8672_13855) | 2955709..2956383 | + | 675 | WP_003413471.1 | pyridoxamine 5'-phosphate oxidase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 147 a.a. Molecular weight: 16026.38 Da Isoelectric Point: 6.8599
>T198487 WP_003413460.1 NZ_CP072762:2951855-2952295 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK
Download Length: 441 bp
>T198487 NZ_CP096848:713392-713793 [Mycobacterium tuberculosis variant bovis]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTGCGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTGCGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA
Antitoxin
Download Length: 96 a.a. Molecular weight: 10453.98 Da Isoelectric Point: 7.2797
>AT198487 WP_003413456.1 NZ_CP072762:2951581-2951868 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL
Download Length: 288 bp
>AT198487 NZ_CP096848:713168-713395 [Mycobacterium tuberculosis variant bovis]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TQK0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BWB8 |