Detailed information of TA system TA198481

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/-
• Location: 2405124..2405653
• Replicon: chromosome
• Accession: NZ_CP072762
• Organism: Mycobacterium tuberculosis strain CG23

Toxin (Protein)

• Gene name: parE
• Uniprot ID: G0TMR4
• Locus tag: J8672_RS11185
• Protein ID: WP_003411124.1
• Coordinates: 2405124..2405441 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: P9WJ74
• Locus tag: J8672_RS11190
• Protein ID: WP_003411127.1
• Coordinates: 2405438..2405653 (-)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J8672_RS11155 (J8672_11155)	2400261..2401337	+	1077	WP_003411110.1	hypothetical protein	-
J8672_RS11160 (J8672_11160)	2401334..2401615	+	282	WP_003411112.1	DUF5703 family protein	-
J8672_RS11165 (J8672_11165)	2401651..2402724	+	1074	WP_003411116.1	quinone-dependent dihydroorotate dehydrogenase	-
J8672_RS11170 (J8672_11170)	2402729..2403259	-	531	WP_003411119.1	YbhB/YbcL family Raf kinase inhibitor-like protein	-
J8672_RS11175 (J8672_11175)	2403307..2404653	-	1347	WP_003411121.1	M20/M25/M40 family metallo-hydrolase	-
J8672_RS11185 (J8672_11185)	2405124..2405441	-	318	WP_003411124.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
J8672_RS11190 (J8672_11190)	2405438..2405653	-	216	WP_003411127.1	antitoxin ParD2	Antitoxin
J8672_RS11195 (J8672_11195)	2405908..2406966	+	1059	WP_003411129.1	phosphoribosyltransferase family protein	-
J8672_RS11200 (J8672_11200)	2407096..2407452	-	357	WP_003411130.1	hypothetical protein	-
J8672_RS11205 (J8672_11205)	2407547..2408329	-	783	WP_003411131.1	cell wall synthesis protein Wag31	-
J8672_RS11210 (J8672_11210)	2408597..2408887	-	291	WP_003900476.1	YggT family protein	-
J8672_RS11215 (J8672_11215)	2409049..2409705	-	657	WP_003411133.1	cell division protein SepF	-
J8672_RS11220 (J8672_11220)	2409771..2410547	-	777	WP_003411137.1	YggS family pyridoxal phosphate-dependent enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-92)

Antitoxin

• Conserved hypothetical protein CHP02574, addiction module (11-69)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12312.88 Da
• Isoelectric Point: 6.4831

>T198481 WP_003411124.1 NZ_CP072762:c2405441-2405124 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Nucleotide

• Length: 318 bp

>T198481 NZ_CP096848:364975-365400 [Mycobacterium tuberculosis variant bovis]
GTGACTGACCAGCGCTGGCTGATCGACAAGTCGGCGCTGGTGCGGCTCACGGACAGCCCTGACATGGAAATCTGGTCGAA
CCGGATCGAACGCGGCCTGGTACACATCACGGGCGTGACACGCTTGGAAGTAGGGTTCTCGGCCGAATGCGGGGAGATAG
CGCGACGGGAGTTTCGTGAACCGCCGCTGTCTGCGATGCCCGTGGAATACCTAACCCCGAGAATTGAAGACCGTGCGCTC
GAGGTGCAGACCTTGCTTGCCGACCGCGGACACCACCGTGGCCCGTCGATCCCGGATCTGCTCATCGCCGCGACAGCCGA
ACTGTCGGGCTTGACGGTACTGCACGTCGACAAGGACTTTGACGCCATCGCCGCGCTTACCGGTCAGAAAACAGAACGGC
TCACGCATCGCCCGCCTTCCGCTTAA

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 7880.70 Da
• Isoelectric Point: 4.4055

>AT198481 WP_003411127.1 NZ_CP072762:c2405653-2405438 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Nucleotide

• Length: 216 bp

>AT198481 NZ_CP096848:364757-364978 [Mycobacterium tuberculosis variant bovis]
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA

Structures

Toxin

• AlphaFold DB: G0TMR4

Antitoxin

• AlphaFold DB: A0A7U4FAJ4