Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2260976..2261602 Replicon chromosome
Accession NZ_CP072762
Organism Mycobacterium tuberculosis strain CG23

Toxin (Protein)


Gene name vapC Uniprot ID P64926
Locus tag J8672_RS10515 Protein ID WP_003410075.1
Coordinates 2261204..2261602 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A806JLL8
Locus tag J8672_RS10510 Protein ID WP_003911750.1
Coordinates 2260976..2261203 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8672_RS10500 (J8672_10500) 2259015..2259359 - 345 WP_003410065.1 ferredoxin family protein -
J8672_RS10505 (J8672_10505) 2259548..2260717 - 1170 WP_003899126.1 ATP-binding protein -
J8672_RS10510 (J8672_10510) 2260976..2261203 + 228 WP_003911750.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
J8672_RS10515 (J8672_10515) 2261204..2261602 + 399 WP_003410075.1 PIN domain nuclease Toxin
J8672_RS10520 (J8672_10520) 2261785..2262216 - 432 WP_003410078.1 MarR family winged helix-turn-helix transcriptional regulator -
J8672_RS10525 (J8672_10525) 2262317..2262751 + 435 WP_003914358.1 DUF1398 domain-containing protein -
J8672_RS10530 (J8672_10530) 2263188..2263367 - 180 Protein_2104 hypothetical protein -
J8672_RS10535 (J8672_10535) 2263461..2264075 + 615 WP_234715470.1 IS110 family transposase -
J8672_RS10540 (J8672_10540) 2264029..2264619 + 591 WP_003899131.1 IS110 family transposase -
J8672_RS10545 (J8672_10545) 2264747..2266003 - 1257 WP_003410095.1 HNH endonuclease signature motif containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-43)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14731.02 Da        Isoelectric Point: 6.7067

>T198477 WP_003410075.1 NZ_CP072762:2261204-2261602 [Mycobacterium tuberculosis]
MIVDTSVWIAYLSTSESLASRWLADRIAADSTVIVPEVVMMELLIGKTDEDTAALRRRLLQRFAIEPLAPVRDAEDAAAI
HRRCRRGGDTVRSLIDCQVAAMALRIGVAVAHRDRDYEAIRTHCGLRTEPLF

Download         Length: 399 bp

>T198477 NZ_CP096847:3777905-3778315 [Mycobacterium tuberculosis variant bovis]
GTGATCTATATGGACACCTCGGCCCTGACTAAGCTGCTCATCTCCGAGCCCGAGACGACCGAACTGCGGACATGGCTGAC
CGCGCAAAGCGGCCAGGGCGAGGACGCGGCGACAAGCACCCTTGGCCGGGTCGAGTTGATGAGAGTCGTTGCCCGATACG
GACAACCAGGCCAAACTGAGCGTGCGCGTTACCTACTCGACGGGCTCGACATCCTCCCGCTCACCGAACCGGTGATCGGT
CTAGCTGAAACGATCGGACCGGCCACCCTACGTTCTCTCGACGCGATTCACCTCGCGGCCGCAGCCCAGATCAAGCGGGA
ACTGACAGCCTTCGTCACCTACGACCACCGATTGTTGAGCGGATGCCGTGAGGTCGGCTTCGTCACCGCCTCACCCGGCG
CAGTCCGGTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8346.16 Da        Isoelectric Point: 4.1621

>AT198477 WP_003911750.1 NZ_CP072762:2260976-2261203 [Mycobacterium tuberculosis]
VSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGEPLGRDEALALQGSGFDFSNDEIESFSDTDRKLADES

Download         Length: 228 bp

>AT198477 NZ_CP096847:3777630-3777908 [Mycobacterium tuberculosis variant bovis]
GTGGAGGCAATCGGAATCCGAGAACTAAGACAGCACGCATCGCGATACCTCGCCCGGGTTGAAGCCGGCGAGGAACTTGG
CGTCACCAACAAAGGAAGACTTGTGGCCCGACTCATCCCGGTGCAGGCCGCGGAGCGTTCTCGCGAAGCCCTGATTGAAT
CAGGTGTCCTGATTCCGGCTCGTCGTCCACAAAACCTTCTCGACGTCACCGCCGAACCGGCGCGCGGCCGCAAGCGCACC
CTGTCCGATGTTCTCAACGAAATGCGCGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4CHG

Antitoxin

Source ID Structure
AlphaFold DB A0A806JLL8

References