Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2206611..2207155 | Replicon | chromosome |
| Accession | NZ_CP072762 | ||
| Organism | Mycobacterium tuberculosis strain CG23 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | J8672_RS10225 | Protein ID | WP_003409896.1 |
| Coordinates | 2206611..2206907 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | J8672_RS10230 | Protein ID | WP_003409899.1 |
| Coordinates | 2206904..2207155 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J8672_RS10170 (J8672_10170) | 2201644..2201994 | - | 351 | WP_003899096.1 | hypothetical protein | - |
| J8672_RS10175 (J8672_10175) | 2202005..2202907 | - | 903 | WP_003899097.1 | hypothetical protein | - |
| J8672_RS10180 (J8672_10180) | 2202928..2203119 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| J8672_RS10185 (J8672_10185) | 2203120..2203416 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| J8672_RS10190 (J8672_10190) | 2203656..2203871 | + | 216 | WP_003409878.1 | antitoxin | - |
| J8672_RS10195 (J8672_10195) | 2203868..2204179 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| J8672_RS10200 (J8672_10200) | 2204153..2204674 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| J8672_RS10205 (J8672_10205) | 2204649..2205026 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| J8672_RS10210 (J8672_10210) | 2205068..2205517 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| J8672_RS10215 (J8672_10215) | 2205514..2206059 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| J8672_RS10220 (J8672_10220) | 2205948..2206562 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| J8672_RS10225 (J8672_10225) | 2206611..2206907 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| J8672_RS10230 (J8672_10230) | 2206904..2207155 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| J8672_RS10235 (J8672_10235) | 2207142..2207636 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| J8672_RS10240 (J8672_10240) | 2207796..2208203 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| J8672_RS10245 (J8672_10245) | 2208207..2208479 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| J8672_RS10250 (J8672_10250) | 2208512..2209732 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| J8672_RS10255 (J8672_10255) | 2210631..2211428 | + | 798 | WP_003899101.1 | ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T198473 WP_003409896.1 NZ_CP072762:c2206907-2206611 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T198473 NZ_CP096847:3506601-3506945 [Mycobacterium tuberculosis variant bovis]
TTGGCCGTGATCCTGCTCCCGCAGGTCGAACGGTGGTTCTTCGCGCTCAACAGGGATGCGATGGCCTCGGTCACCGGCGC
CATCGACCTGCTCGAAATGGAGGGGCCGACGTTGGGCCGCCCGGTGGTCGACAAAGTGAACGACTCAACGTTTCACAACA
TGAAGGAGCTGCGCCCCGCCGGCACCAGCATCCGGATCCTGTTCGCCTTCGACCCGGCCCGGCAGGCGATCCTGCTGCTG
GGCGGTGACAAGGCAGGCAACTGGAAACGCTGGTACGACAACAACATTCCAATCGCTGACCAGCGCTCCGAGAACTGGCT
GGCGAGCGAGCACGGAGGTGGATGA
TTGGCCGTGATCCTGCTCCCGCAGGTCGAACGGTGGTTCTTCGCGCTCAACAGGGATGCGATGGCCTCGGTCACCGGCGC
CATCGACCTGCTCGAAATGGAGGGGCCGACGTTGGGCCGCCCGGTGGTCGACAAAGTGAACGACTCAACGTTTCACAACA
TGAAGGAGCTGCGCCCCGCCGGCACCAGCATCCGGATCCTGTTCGCCTTCGACCCGGCCCGGCAGGCGATCCTGCTGCTG
GGCGGTGACAAGGCAGGCAACTGGAAACGCTGGTACGACAACAACATTCCAATCGCTGACCAGCGCTCCGAGAACTGGCT
GGCGAGCGAGCACGGAGGTGGATGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT198473 WP_003409899.1 NZ_CP072762:c2207155-2206904 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT198473 NZ_CP096847:3506942-3507271 [Mycobacterium tuberculosis variant bovis]
ATGACCATGGCCCGCAACTGGCGTGACATTCGCGCCGATGCCGTCGCGCAGGGCCGCGTGGATCTGCAGCGGGCCGCCGT
GGCACGCGAGGAGATGCGCGATGCCGTCCTGGCGCACCGCCTGGCCGAGATCCGCAAGGCGCTAGGCCACGCACGTCAGG
CCGACGTCGCGGCGCTGATGGGGGTCTCTCAGGCCCGTGTCTCCAAGCTGGAGAGCGGCGACCTGTCCCACACCGAACTC
GGCACCCTGCAGGCCTACGTTGCCGCCCTGGGCGGGCACCTGCGCATCGTCGCTGAGTTCGGCGAAAATACTGTCGAGCT
GACCGCCTGA
ATGACCATGGCCCGCAACTGGCGTGACATTCGCGCCGATGCCGTCGCGCAGGGCCGCGTGGATCTGCAGCGGGCCGCCGT
GGCACGCGAGGAGATGCGCGATGCCGTCCTGGCGCACCGCCTGGCCGAGATCCGCAAGGCGCTAGGCCACGCACGTCAGG
CCGACGTCGCGGCGCTGATGGGGGTCTCTCAGGCCCGTGTCTCCAAGCTGGAGAGCGGCGACCTGTCCCACACCGAACTC
GGCACCCTGCAGGCCTACGTTGCCGCCCTGGGCGGGCACCTGCGCATCGTCGCTGAGTTCGGCGAAAATACTGTCGAGCT
GACCGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |