198446

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 677713..678332 Replicon chromosome
Accession NZ_CP072762
Organism Mycobacterium tuberculosis strain CG23

Toxin (Protein)


Gene name vapC Uniprot ID O53779
Locus tag J8672_RS03035 Protein ID WP_003403047.1
Coordinates 677925..678332 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O53778
Locus tag J8672_RS03030 Protein ID WP_003403039.1
Coordinates 677713..677928 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8672_RS03020 (J8672_03020) 676241..676999 + 759 WP_003898511.1 Mut7-C RNAse domain-containing protein -
J8672_RS03025 (J8672_03025) 677128..677619 - 492 WP_003403017.1 mycobacterial cell wall protein Rv0580c -
J8672_RS03030 (J8672_03030) 677713..677928 + 216 WP_003403039.1 type II toxin-antitoxin system antitoxin VapB26 Antitoxin
J8672_RS03035 (J8672_03035) 677925..678332 + 408 WP_003403047.1 type II toxin-antitoxin system toxin ribonuclease C26 Toxin
J8672_RS03040 (J8672_03040) 678392..679078 - 687 WP_003403052.1 LpqN/LpqT family lipoprotein -
J8672_RS03045 (J8672_03045) 679232..681865 + 2634 WP_003403055.1 GH92 family glycosyl hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Ribbon-helix-helix protein, CopG

(4-39)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14471.43 Da        Isoelectric Point: 4.4493

>T198446 WP_003403047.1 NZ_CP072762:677925-678332 [Mycobacterium tuberculosis]
VIIDTSALLAYFDAAEPDHAAVSECIDSSADALVVSPYVVAELDYLVATRVGVDAELAVLRELAGGAWELANCGAAEIEQ
AARIVTKYQDQRIGIADAANVVLADRYRTRTILTLDRRHFSALRPIGGGRFTVIP

Download         Length: 408 bp

>T198446 NZ_CP096847:1689081-1689398 [Mycobacterium tuberculosis variant bovis]
GTGAACGCGCCGTTGCGTGGTCAGGTCTATCGATGCGACCTCGGATACGGGGCCAAACCGTGGCTCATCGTCTCCAACAA
CGCCCGCAACCGTCACACCGCCGACGTGGTGGCTGTGCGCCTGACAACAACGCGGAGAACCATACCGACCTGGGTCGCCA
TGGGCCCCAGCGATCCATTGACCGGATACGTCAACGCGGACAACATCGAGACCCTCGGCAAAGACGAGCTCGGTGACTAC
CTCGGTGAGGTCACGCCGGCGACGATGAACAAAATCAACACGGCGCTCGCGACCGCGCTGGGGCTACCGTGGCCATGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7572.66 Da        Isoelectric Point: 10.5454

>AT198446 WP_003403039.1 NZ_CP072762:677713-677928 [Mycobacterium tuberculosis]
VDKTTVYLPDELKAAVKRAARQRGVSEAQVIRESIRAAVGGAKPPPRGGLYAGSEPIARRVDELLAGFGER

Download         Length: 216 bp

>AT198446 NZ_CP096847:1688782-1689084 [Mycobacterium tuberculosis variant bovis]
GTGCCGTTTCTGGTTGCATTATCCGGTATCATCTCGGGCGTGCGTGATCATTCGATGACCGTGCGGCTCGACCAGCAAAC
TCGCCAGCGCCTGCAAGACATTGTGAAAGGCGGATACCGGAGCGCTAATGCGGCGATCGTCGACGCCATCAACAAGCGCT
GGGAGGCGCTACACGATGAGCAACTCGACGCCGCCTACGCGGCCGCGATCCATGACAATCCGGCGTACCCGTACGAGTCT
GAGGCCGAACGGAGCGCCGCGCGGGCCCGGCGCAACGCCAGGCAGCAGCGCTCGGCACAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5X3T

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSA2

References