Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3225984..3226532 Replicon chromosome
Accession NZ_CP072761
Organism Mycobacterium tuberculosis strain CG24

Toxin (Protein)


Gene name relE Uniprot ID G0TFG5
Locus tag J8670_RS15340 Protein ID WP_003414602.1
Coordinates 3226269..3226532 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O33347
Locus tag J8670_RS15335 Protein ID WP_003414599.1
Coordinates 3225984..3226265 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8670_RS15310 (J8670_15310) 3221607..3222464 - 858 WP_003899513.1 type I methionyl aminopeptidase -
J8670_RS15315 (J8670_15315) 3222506..3223090 - 585 WP_003899514.1 DUF1707 domain-containing protein -
J8670_RS15320 (J8670_15320) 3223194..3223442 + 249 WP_003913411.1 antitoxin VapB23 -
J8670_RS15325 (J8670_15325) 3223439..3223819 + 381 WP_003414592.1 type II toxin-antitoxin system VapC family toxin -
J8670_RS15330 (J8670_15330) 3223901..3225712 - 1812 WP_003414596.1 penicillin-binding protein -
J8670_RS15335 (J8670_15335) 3225984..3226265 + 282 WP_003414599.1 type II toxin-antitoxin system antitoxin RelF Antitoxin
J8670_RS15340 (J8670_15340) 3226269..3226532 + 264 WP_003414602.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J8670_RS15345 (J8670_15345) 3226905..3227759 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
J8670_RS15350 (J8670_15350) 3227815..3228978 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
J8670_RS15355 (J8670_15355) 3228995..3230209 - 1215 WP_003899518.1 zinc metalloprotease Rip -
J8670_RS15360 (J8670_15360) 3230217..3231458 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10204.82 Da        Isoelectric Point: 11.5078

>T198433 WP_003414602.1 NZ_CP072761:3226269-3226532 [Mycobacterium tuberculosis]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Download         Length: 264 bp

>T198433 NZ_CP096847:c756169-755786 [Mycobacterium tuberculosis variant bovis]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10183.40 Da        Isoelectric Point: 4.3440

>AT198433 WP_003414599.1 NZ_CP072761:3225984-3226265 [Mycobacterium tuberculosis]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Download         Length: 282 bp

>AT198433 NZ_CP096847:c756419-756264 [Mycobacterium tuberculosis variant bovis]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3G5O

Antitoxin

Source ID Structure
PDB 3G5O
AlphaFold DB A0A7U4BWP8

References