Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/PIN(toxin) |
| Location | 2978517..2979231 | Replicon | chromosome |
| Accession | NZ_CP072761 | ||
| Organism | Mycobacterium tuberculosis strain CG24 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | G0TQK0 |
| Locus tag | J8670_RS13955 | Protein ID | WP_003413460.1 |
| Coordinates | 2978791..2979231 (+) | Length | 147 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | P9WJ20 |
| Locus tag | J8670_RS13950 | Protein ID | WP_003413456.1 |
| Coordinates | 2978517..2978804 (+) | Length | 96 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J8670_RS13915 (J8670_13915) | 2973939..2974184 | + | 246 | WP_003413429.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| J8670_RS13920 (J8670_13920) | 2974181..2974585 | + | 405 | WP_003899389.1 | type II toxin-antitoxin system VapC family toxin | - |
| J8670_RS13925 (J8670_13925) | 2974802..2975422 | + | 621 | WP_003413441.1 | DUF4178 domain-containing protein | - |
| J8670_RS13930 (J8670_13930) | 2975433..2975927 | + | 495 | WP_003413444.1 | DUF2617 family protein | - |
| J8670_RS13935 (J8670_13935) | 2975924..2976355 | + | 432 | WP_003899390.1 | DUF4247 domain-containing protein | - |
| J8670_RS13940 (J8670_13940) | 2976410..2976838 | + | 429 | WP_178121172.1 | DUF350 domain-containing protein | - |
| J8670_RS13945 (J8670_13945) | 2976835..2978406 | + | 1572 | WP_003899392.1 | polyamine aminopropyltransferase | - |
| J8670_RS13950 (J8670_13950) | 2978517..2978804 | + | 288 | WP_003413456.1 | antitoxin VapB41 | Antitoxin |
| J8670_RS13955 (J8670_13955) | 2978791..2979231 | + | 441 | WP_003413460.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| J8670_RS13960 (J8670_13960) | 2979252..2980007 | - | 756 | WP_003413464.1 | YebC/PmpR family DNA-binding transcriptional regulator | - |
| J8670_RS13965 (J8670_13965) | 2980140..2980736 | - | 597 | WP_003413465.1 | pyridoxal 5'-phosphate synthase glutaminase subunit PdxT | - |
| J8670_RS13970 (J8670_13970) | 2980744..2981589 | - | 846 | WP_003413466.1 | acyl-CoA thioesterase II | - |
| J8670_RS13975 (J8670_13975) | 2981618..2982517 | - | 900 | WP_003413468.1 | pyridoxal 5'-phosphate synthase lyase subunit PdxS | - |
| J8670_RS13980 (J8670_13980) | 2982645..2983319 | + | 675 | WP_003413471.1 | pyridoxamine 5'-phosphate oxidase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 147 a.a. Molecular weight: 16026.38 Da Isoelectric Point: 6.8599
>T198426 WP_003413460.1 NZ_CP072761:2978791-2979231 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK
Download Length: 441 bp
>T198426 NZ_CP096847:680194-680601 [Mycobacterium tuberculosis variant bovis]
GTGATCATCGACACGAGTGCGCTGCTTGCCTATTTCGACGCCGCCGAGCCAGACCACGCCGCAGTGTCTGAGTGCATCGA
TAGCTCCGCAGACGCGCTCGTCGTATCCCCTTATGTGGTAGCGGAACTCGACTATCTCGTCGCCACCCGGGTAGGTGTCG
ATGCCGAGCTCGCCGTCCTGCGTGAACTCGCCGGCGGGGCCTGGGAGCTCGCCAACTGCGGTGCCGCCGAAATCGAGCAG
GCCGCCCGCATCGTCACGAAATACCAGGATCAGCGGATCGGGATCGCGGATGCGGCCAACGTCGTGCTGGCCGACCGATA
CCGCACGCGCACGATCCTCACCCTGGACCGTCGGCACTTCTCGGCGCTGCGGCCGATCGGCGGTGGGCGCTTCACCGTCA
TTCCGTAA
GTGATCATCGACACGAGTGCGCTGCTTGCCTATTTCGACGCCGCCGAGCCAGACCACGCCGCAGTGTCTGAGTGCATCGA
TAGCTCCGCAGACGCGCTCGTCGTATCCCCTTATGTGGTAGCGGAACTCGACTATCTCGTCGCCACCCGGGTAGGTGTCG
ATGCCGAGCTCGCCGTCCTGCGTGAACTCGCCGGCGGGGCCTGGGAGCTCGCCAACTGCGGTGCCGCCGAAATCGAGCAG
GCCGCCCGCATCGTCACGAAATACCAGGATCAGCGGATCGGGATCGCGGATGCGGCCAACGTCGTGCTGGCCGACCGATA
CCGCACGCGCACGATCCTCACCCTGGACCGTCGGCACTTCTCGGCGCTGCGGCCGATCGGCGGTGGGCGCTTCACCGTCA
TTCCGTAA
Antitoxin
Download Length: 96 a.a. Molecular weight: 10453.98 Da Isoelectric Point: 7.2797
>AT198426 WP_003413456.1 NZ_CP072761:2978517-2978804 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL
Download Length: 288 bp
>AT198426 NZ_CP096847:679982-680197 [Mycobacterium tuberculosis variant bovis]
GTGGACAAGACGACGGTCTACCTGCCGGATGAACTCAAGGCGGCCGTGAAGCGCGCCGCTCGGCAGCGCGGAGTCTCCGA
AGCGCAGGTAATCCGGGAGTCCATCCGGGCGGCGGTCGGCGGCGCCAAGCCGCCGCCGCGCGGGGGTCTATATGCGGGTT
CGGAGCCCATCGCGCGGCGAGTCGACGAGCTGCTGGCTGGCTTCGGTGAGCGGTGA
GTGGACAAGACGACGGTCTACCTGCCGGATGAACTCAAGGCGGCCGTGAAGCGCGCCGCTCGGCAGCGCGGAGTCTCCGA
AGCGCAGGTAATCCGGGAGTCCATCCGGGCGGCGGTCGGCGGCGCCAAGCCGCCGCCGCGCGGGGGTCTATATGCGGGTT
CGGAGCCCATCGCGCGGCGAGTCGACGAGCTGCTGGCTGGCTTCGGTGAGCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TQK0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BWB8 |