Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC(toxin) |
| Location | 2916601..2917310 | Replicon | chromosome |
| Accession | NZ_CP072761 | ||
| Organism | Mycobacterium tuberculosis strain CG24 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | G0TQ26 |
| Locus tag | J8670_RS13670 | Protein ID | WP_003413164.1 |
| Coordinates | 2916601..2917014 (+) | Length | 138 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | P95006 |
| Locus tag | J8670_RS13675 | Protein ID | WP_003413167.1 |
| Coordinates | 2917053..2917310 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J8670_RS13640 (J8670_13640) | 2911654..2912859 | - | 1206 | WP_003413027.1 | chorismate synthase | - |
| J8670_RS13645 (J8670_13645) | 2912967..2913281 | + | 315 | WP_009937839.1 | hypothetical protein | - |
| J8670_RS13650 (J8670_13650) | 2913577..2914788 | + | 1212 | WP_009936235.1 | alpha/beta hydrolase family protein | - |
| J8670_RS13655 (J8670_13655) | 2914915..2915574 | + | 660 | WP_003900846.1 | LppA family lipoprotein | - |
| J8670_RS13660 (J8670_13660) | 2915571..2916233 | + | 663 | WP_003900848.1 | LppA family lipoprotein | - |
| J8670_RS13665 (J8670_13665) | 2916230..2916508 | + | 279 | WP_003901422.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| J8670_RS13670 (J8670_13670) | 2916601..2917014 | + | 414 | WP_003413164.1 | PIN domain nuclease | Toxin |
| J8670_RS13675 (J8670_13675) | 2917053..2917310 | + | 258 | WP_003413167.1 | CopG family transcriptional regulator | Antitoxin |
| J8670_RS13680 (J8670_13680) | 2917307..2917684 | + | 378 | WP_003413174.1 | type II toxin-antitoxin system VapC family toxin | - |
| J8670_RS13685 (J8670_13685) | 2917700..2918074 | - | 375 | WP_003413177.1 | hypothetical protein | - |
| J8670_RS13690 (J8670_13690) | 2918174..2918569 | - | 396 | WP_003413180.1 | type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 | - |
| J8670_RS13695 (J8670_13695) | 2918566..2918811 | - | 246 | WP_003413183.1 | type II toxin-antitoxin system antitoxin VapB20 | - |
| J8670_RS13700 (J8670_13700) | 2919222..2919641 | - | 420 | WP_003413190.1 | A24 family peptidase | - |
| J8670_RS13705 (J8670_13705) | 2919653..2920462 | - | 810 | WP_003413193.1 | shikimate dehydrogenase | - |
| J8670_RS13710 (J8670_13710) | 2920459..2921712 | - | 1254 | WP_003413196.1 | endolytic transglycosylase MltG | - |
| J8670_RS13715 (J8670_13715) | 2921705..2922217 | - | 513 | WP_003413197.1 | Holliday junction resolvase RuvX | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 138 a.a. Molecular weight: 15045.00 Da Isoelectric Point: 5.4673
>T198423 WP_003413164.1 NZ_CP072761:2916601-2917014 [Mycobacterium tuberculosis]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL
Download Length: 414 bp
>T198423 NZ_CP096847:364409-364711 [Mycobacterium tuberculosis variant bovis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG
Antitoxin
Download Length: 86 a.a. Molecular weight: 9453.63 Da Isoelectric Point: 10.6555
>AT198423 WP_003413167.1 NZ_CP072761:2917053-2917310 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA
Download Length: 258 bp
>AT198423 NZ_CP096847:364759-364980 [Mycobacterium tuberculosis variant bovis]
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TQ26 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829C9W5 |