Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 131005..131540 Replicon plasmid pR28_180
Accession NZ_CP072743
Organism Serratia fonticola strain R28

Toxin (Protein)


Gene name relE Uniprot ID A0A1Q5UY82
Locus tag J8M99_RS25660 Protein ID WP_074032217.1
Coordinates 131253..131540 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1Q5UY56
Locus tag J8M99_RS25655 Protein ID WP_074032216.1
Coordinates 131005..131256 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8M99_RS25640 (J8M99_25630) 126981..128174 + 1194 WP_218520429.1 conjugal transfer protein TraW -
J8M99_RS25645 (J8M99_25635) 128174..128683 + 510 WP_218520430.1 conjugal transfer protein TraX -
J8M99_RS25650 (J8M99_25640) 128751..130898 + 2148 WP_074032215.1 DotA/TraY family protein -
J8M99_RS25655 (J8M99_25645) 131005..131256 + 252 WP_074032216.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
J8M99_RS25660 (J8M99_25650) 131253..131540 + 288 WP_074032217.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J8M99_RS25665 (J8M99_25655) 131559..132233 + 675 WP_218520431.1 plasmid IncI1-type surface exclusion protein ExcA -
J8M99_RS25670 (J8M99_25660) 132325..133584 + 1260 WP_218520432.1 conjugal transfer protein TrbA -
J8M99_RS25675 (J8M99_25665) 133589..134656 + 1068 WP_218520433.1 thioredoxin fold domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..180139 180139


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11067.99 Da        Isoelectric Point: 10.5846

>T198378 WP_074032217.1 NZ_CP072743:131253-131540 [Serratia fonticola]
MTYKVKFRTDALKEWNSLDRSIQQQFAKKLKKCTENPHIPSAKLRGMPDCYKIKLRASGFRLVYQVINDELIIAVVAVGK
REHSEVYNQASKRLK

Download         Length: 288 bp

>T198378 NZ_CP096846:c757108-756671 [Mycobacterium tuberculosis variant bovis]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9415.66 Da        Isoelectric Point: 4.3000

>AT198378 WP_074032216.1 NZ_CP072743:131005-131256 [Serratia fonticola]
MPNIIHSTMTASITELKTNPMATVNSGEGYPVAILNRNQPAFYCIPAALYEQMLEYIDDQELANLVKERSEQTLHDVNLD
RYV

Download         Length: 252 bp

>AT198378 NZ_CP096846:c756561-756316 [Mycobacterium tuberculosis variant bovis]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q5UY82

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q5UY56

References