Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 51191..51710 Replicon plasmid pR28_180
Accession NZ_CP072743
Organism Serratia fonticola strain R28

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag J8M99_RS25280 Protein ID WP_209524156.1
Coordinates 51423..51710 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag J8M99_RS25275 Protein ID WP_209524157.1
Coordinates 51191..51433 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8M99_RS25255 (J8M99_25245) 46663..47433 - 771 WP_218520486.1 N-6 DNA methylase -
J8M99_RS25260 (J8M99_25250) 48025..48483 - 459 WP_218520487.1 IS200/IS605-like element IS1541C family transposase -
J8M99_RS25265 (J8M99_25255) 48715..49686 - 972 WP_218520488.1 ParB family protein -
J8M99_RS25270 (J8M99_25260) 49695..50888 - 1194 WP_209524158.1 AAA family ATPase -
J8M99_RS25275 (J8M99_25265) 51191..51433 + 243 WP_209524157.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
J8M99_RS25280 (J8M99_25270) 51423..51710 + 288 WP_209524156.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J8M99_RS25285 (J8M99_25275) 51959..52771 - 813 WP_218520489.1 tyrosine-type recombinase/integrase -
J8M99_RS25290 (J8M99_25280) 52768..53052 - 285 WP_218520490.1 hypothetical protein -
J8M99_RS25295 (J8M99_25285) 53856..54707 - 852 WP_218520491.1 winged helix-turn-helix domain-containing protein -
J8M99_RS25300 (J8M99_25290) 55406..55786 + 381 WP_218520492.1 helix-turn-helix domain-containing protein -
J8M99_RS25305 (J8M99_25295) 55898..56446 + 549 WP_218520493.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..180139 180139


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11009.95 Da        Isoelectric Point: 10.3023

>T198377 WP_209524156.1 NZ_CP072743:51423-51710 [Serratia fonticola]
MTYKIDFDNAAFKEWKKLGETVRQQLKKKLAQIVEAPRVEANRLHSLPDCYKIKLRASGYRLVYKVEDETVVILVLAVGK
RERLEVYKAAATRLS

Download         Length: 288 bp

>T198377 NZ_CP096846:c756329-756021 [Mycobacterium tuberculosis variant bovis]
ATGCGGCGCGGTGAATTGTGGTTTGCCGCCACACCTGGTGGTGACAGACCAGTACTTGTCCTTACCAGAGATCCGGTGGC
AGACCGCATCGGCGCGGTCGTTGTGGTGGCCCTAACCCGCACCCGCCGAGGCCTGGTGTCGGAATTGGAGCTCACGGCCG
TCGAAAACCGTGTTCCGAGCGACTGCGTCGTCAACTTCGACAACATTCATACGTTGCCACGCACCGCATTCCGACGCCGC
ATCACCCGGCTGTCCCCGGCCCGCCTGCACGAAGCCTGTCAAACACTCCGGGCGAGCACGGGGTGTTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8740.05 Da        Isoelectric Point: 4.3951

>AT198377 WP_209524157.1 NZ_CP072743:51191-51433 [Serratia fonticola]
MGTMNIRIDDDLKARAGVALDGLGITASEAVRLVLEYIAQNNRLPVQVALLADEDADIIELARERLANPGKRIRVTLDDL

Download         Length: 243 bp

>AT198377 NZ_CP096846:c756561-756316 [Mycobacterium tuberculosis variant bovis]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References