198367

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3261861..3262517 Replicon chromosome
Accession NZ_CP072742
Organism Serratia fonticola strain R28

Toxin (Protein)


Gene name vapC Uniprot ID A0A0U4J950
Locus tag J8M99_RS14940 Protein ID WP_021807143.1
Coordinates 3262128..3262517 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U2NVJ4
Locus tag J8M99_RS14935 Protein ID WP_021178792.1
Coordinates 3261861..3262124 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8M99_RS14920 (J8M99_14910) 3258206..3259105 - 900 WP_209554891.1 lipid kinase YegS -
J8M99_RS14925 (J8M99_14915) 3259642..3260994 - 1353 WP_021178794.1 tRNA 5-hydroxyuridine modification protein YegQ -
J8M99_RS14930 (J8M99_14920) 3261175..3261513 - 339 WP_021178793.1 YegP family protein -
J8M99_RS14935 (J8M99_14925) 3261861..3262124 + 264 WP_021178792.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
J8M99_RS14940 (J8M99_14930) 3262128..3262517 + 390 WP_021807143.1 type II toxin-antitoxin system VapC family toxin Toxin
J8M99_RS14945 (J8M99_14935) 3262521..3263237 - 717 WP_021807142.1 two-component system response regulator BaeR -
J8M99_RS14950 (J8M99_14940) 3263250..3264620 - 1371 WP_218519040.1 two-component system sensor histidine kinase BaeS -
J8M99_RS14955 (J8M99_14945) 3264617..3266062 - 1446 WP_218519041.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14260.54 Da        Isoelectric Point: 7.8799

>T198367 WP_021807143.1 NZ_CP072742:3262128-3262517 [Serratia fonticola]
MYMFDTNTVSQLFRQHPRLLAAMGRVPPSSVCISSITQAELLYGVAKRQNKALKQTVMMFLDAVTVYSWDSAAAHCYGVM
RASMEKQGRPMGALDQLIAAHAVSRGATIVTSDRAFTMVAELEVEDWTL

Download         Length: 390 bp

>T198367 NZ_CP096846:364995-365420 [Mycobacterium tuberculosis variant bovis]
GTGACTGACCAGCGCTGGCTGATCGACAAGTCGGCGCTGGTGCGGCTCACGGACAGCCCTGACATGGAAATCTGGTCGAA
CCGGATCGAACGCGGCCTGGTACACATCACGGGCGTGACACGCTTGGAAGTAGGGTTCTCGGCCGAATGCGGGGAGATAG
CGCGACGGGAGTTTCGTGAACCGCCGCTGTCTGCGATGCCCGTGGAATACCTAACCCCGAGAATTGAAGACCGTGCGCTC
GAGGTGCAGACCTTGCTTGCCGACCGCGGACACCACCGTGGCCCGTCGATCCCGGATCTGCTCATCGCCGCGACAGCCGA
ACTGTCGGGCTTGACGGTACTGCACGTCGACAAGGACTTTGACGCCATCGCCGCGCTTACCGGTCAGAAAACAGAACGGC
TCACGCATCGCCCGCCTTCCGCTTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10157.53 Da        Isoelectric Point: 4.8232

>AT198367 WP_021178792.1 NZ_CP072742:3261861-3262124 [Serratia fonticola]
MERVAKLFKNGRNQAVRLPVEFEFDVDQVYIRRDEQGNVILSKHPMKLDSWQPLLTMLQNVAVPADFLTADDRQQGVAER
DPFKEEQ

Download         Length: 264 bp

>AT198367 NZ_CP096846:364777-364998 [Mycobacterium tuberculosis variant bovis]
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U4J950

Antitoxin

Source ID Structure
AlphaFold DB U2NVJ4

References