Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 3052537..3053180 Replicon chromosome
Accession NZ_CP072742
Organism Serratia fonticola strain R28

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag J8M99_RS13920 Protein ID WP_059201614.1
Coordinates 3052764..3053180 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag J8M99_RS13915 Protein ID WP_059201615.1
Coordinates 3052537..3052767 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8M99_RS13900 (J8M99_13890) 3049753..3050457 - 705 WP_021807596.1 tRNA-uridine aminocarboxypropyltransferase -
J8M99_RS13905 (J8M99_13895) 3050574..3050993 - 420 WP_021807597.1 thioredoxin TrxC -
J8M99_RS13910 (J8M99_13900) 3051190..3052281 + 1092 WP_021178989.1 tRNA/rRNA methyltransferase -
J8M99_RS13915 (J8M99_13905) 3052537..3052767 + 231 WP_059201615.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
J8M99_RS13920 (J8M99_13910) 3052764..3053180 + 417 WP_059201614.1 PIN domain-containing protein Toxin
J8M99_RS13925 (J8M99_13915) 3053388..3054830 + 1443 WP_218518978.1 IS1182 family transposase -
J8M99_RS13930 (J8M99_13920) 3055188..3055922 + 735 WP_218518979.1 DUF3800 domain-containing protein -
J8M99_RS13935 (J8M99_13925) 3056440..3057975 - 1536 WP_021178986.1 multidrug efflux MFS transporter permease subunit EmrB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3053388..3054830 1442


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-54)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15091.45 Da        Isoelectric Point: 9.2042

>T198366 WP_059201614.1 NZ_CP072742:3052764-3053180 [Serratia fonticola]
MNKTYMLDTNICSFIMREQPEAVIRRLEQTVLRNHRIVVSAITYAEMRFGAIGKKASPRHVRLVDAFCSRLDAVLAWDRA
AVDATTNIKAALAAAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVTGLILEDWAK

Download         Length: 417 bp

>T198366 NZ_CP096846:364427-364729 [Mycobacterium tuberculosis variant bovis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8816.02 Da        Isoelectric Point: 4.3775

>AT198366 WP_059201615.1 NZ_CP072742:3052537-3052767 [Serratia fonticola]
MRIVSVFKNGNNRAIRLPRDMDFDGVSELEIIREGDSIILRPIRPTWGSFLQEEKADADFMMEREGIVSDEGRFEL

Download         Length: 231 bp

>AT198366 NZ_CP096846:364777-364998 [Mycobacterium tuberculosis variant bovis]
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References