Detailed information of TA system TA198365

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 2871426..2872095
• Replicon: chromosome
• Accession: NZ_CP072742
• Organism: Serratia fonticola strain R28

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: J8M99_RS13140
• Protein ID: WP_094981478.1
• Coordinates: 2871673..2872095 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: U2M6Q5
• Locus tag: J8M99_RS13135
• Protein ID: WP_021179805.1
• Coordinates: 2871426..2871692 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J8M99_RS13110 (J8M99_13100)	2867065..2867811	+	747	WP_218518937.1	SDR family oxidoreductase	-
J8M99_RS13115 (J8M99_13105)	2867845..2868453	-	609	WP_094981477.1	HD domain-containing protein	-
J8M99_RS13120 (J8M99_13110)	2868690..2869364	+	675	WP_037375710.1	hemolysin III family protein	-
J8M99_RS13125 (J8M99_13115)	2869596..2870093	+	498	WP_021806198.1	DUF2165 domain-containing protein	-
J8M99_RS13130 (J8M99_13120)	2870133..2871125	-	993	WP_037375809.1	tRNA-modifying protein YgfZ	-
J8M99_RS13135 (J8M99_13125)	2871426..2871692	+	267	WP_021179805.1	FAD assembly factor SdhE	Antitoxin
J8M99_RS13140 (J8M99_13130)	2871673..2872095	+	423	WP_094981478.1	protein YgfX	Toxin
J8M99_RS13145 (J8M99_13135)	2872095..2872790	+	696	WP_021806195.1	two-component system response regulator CreB	-
J8M99_RS13150 (J8M99_13140)	2872787..2874205	+	1419	WP_021806194.1	two-component system sensor histidine kinase CreC	-
J8M99_RS13155 (J8M99_13145)	2874309..2875697	+	1389	WP_059201689.1	cell envelope integrity protein CreD	-
J8M99_RS13160 (J8M99_13150)	2875733..2876251	-	519	WP_021179810.1	flavodoxin FldB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-130)

Antitoxin

• Flavinator of succinate dehydrogenase (7-78)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16497.41 Da
• Isoelectric Point: 10.6373

>T198365 WP_094981478.1 NZ_CP072742:2871673-2872095 [Serratia fonticola]
VALWRCDVRVSWRTQLVSLLTHGLLILLILIAPWPEGYGPIWLVLLTLVVFECIRSQKRIASRQGELRLLAERRIEWHGR
EWLMVNKPWMPGFGILLSLQQIDGKKRHRLWLASDSMSKADWRQLRQRLSFEQSATDEDV

Nucleotide

• Length: 423 bp

>T198365 NZ_CP096846:364427-364729 [Mycobacterium tuberculosis variant bovis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10363.93 Da
• Isoelectric Point: 5.5847

>AT198365 WP_021179805.1 NZ_CP072742:2871426-2871692 [Serratia fonticola]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDADKAVFIRLLECDDPDLFNWLMNHGAPQDQDLQRMVSLIQMRN
KARGPVAM

Nucleotide

• Length: 267 bp

>AT198365 NZ_CP096846:364203-364430 [Mycobacterium tuberculosis variant bovis]
ATGACGAAAGAGAAGATCTCCGTGACGGTGGACGCGGCCGTCCTCGCGGCGATCGACGCGGACGCCAGGGCGGCGGGTTT
GAATCGGTCGGAAATGATTGAGCAGGCACTGCGCAACGAGCACCTGCGTGTCGCTCTGCGCGATTACACGGCTAAAACCG
TACCGGCGTTGGACATCGATGCCTACGCACAGCGGGTGTACCAGGCGAACCGGGCGGCCGGAAGTTGA

Structures

Antitoxin

• AlphaFold DB: U2M6Q5