Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE(toxin)
Location 2524759..2525281 Replicon chromosome
Accession NZ_CP072742
Organism Serratia fonticola strain R28

Toxin (Protein)


Gene name relE Uniprot ID A0A0U4JRE1
Locus tag J8M99_RS11650 Protein ID WP_021806920.1
Coordinates 2524759..2525040 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0U4HY11
Locus tag J8M99_RS11655 Protein ID WP_021806919.1
Coordinates 2525030..2525281 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8M99_RS11635 (J8M99_11630) 2521112..2522377 + 1266 WP_094983168.1 4-aminobutyrate--2-oxoglutarate transaminase -
J8M99_RS11640 (J8M99_11635) 2522390..2523844 + 1455 WP_218520258.1 NAD-dependent succinate-semialdehyde dehydrogenase -
J8M99_RS11645 (J8M99_11640) 2523955..2524590 - 636 WP_218520259.1 glutathione transferase -
J8M99_RS11650 (J8M99_11645) 2524759..2525040 - 282 WP_021806920.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J8M99_RS11655 (J8M99_11650) 2525030..2525281 - 252 WP_021806919.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
J8M99_RS11660 (J8M99_11655) 2525346..2525999 - 654 WP_218520260.1 Qnr family pentapeptide repeat protein -
J8M99_RS11665 (J8M99_11660) 2526193..2526837 + 645 WP_021806917.1 thermostable hemolysin -
J8M99_RS11670 (J8M99_11665) 2526834..2528273 + 1440 WP_218520261.1 AMP-dependent synthetase/ligase -
J8M99_RS11675 (J8M99_11670) 2528270..2528926 + 657 WP_021180630.1 iron-containing redox enzyme family protein -
J8M99_RS11680 (J8M99_11675) 2528923..2529732 + 810 WP_059201891.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10991.89 Da        Isoelectric Point: 10.6704

>T198364 WP_021806920.1 NZ_CP072742:c2525040-2524759 [Serratia fonticola]
MTYKLKFEKRALKEWEKLGYPVREQLKKKLAERLENPHVPASRLSGRPNRYKIKLRSSGYRLVYEVRDNEIVLLVIAVGK
RAGEEVYFAADKR

Download         Length: 282 bp

>T198364 NZ_CP096846:71514-71915 [Mycobacterium tuberculosis variant bovis]
GTGGATGAATGTGTAGTCGACGCGGCGGCCGTGGTTGACGCTCTCGCCGGCAAGGGCGCCAGCGCGATCGTTCTGCGCGG
TTTGCTCAAGGAGTCGATTTCTAACGCGCCGCATTTGCTGGACGCAGAGGTCGGACATGCACTCCGCCGCGCCGTGCTCA
GCGACGAAATCTCCGAAGAGCAGGCTCGCGCCGCGTTGGATGCCTTGCCTTATCTCATCGACAATCGTTACCCGCACAGC
CCACGACTGATCGAATACACATGGCAGCTAAGGCACAACGTCACGTTCTACGACGCCCTTTACGTCGCACTGGCCACCGC
ACTGGATGTCCCGCTGCTCACGGGCGACTCGCGGCTTGCGGCCGCGCCGGGCCTTCCGTGCGAAATCAAACTCGTTCGGT
GA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9243.37 Da        Isoelectric Point: 3.7947

>AT198364 WP_021806919.1 NZ_CP072742:c2525281-2525030 [Serratia fonticola]
MAFQILTTIAASITDLKKNPMGTVADGEGEAVAILNRNEPAFYCVPPELYAYYRELAEDAELNRIADERMEDAEFVSVDL
NDL

Download         Length: 252 bp

>AT198364 NZ_CP096846:71282-71521 [Mycobacterium tuberculosis variant bovis]
ATGGCTACCATTCAAGTTCGGGATTTGCCCGAAGATGTCGCCGAAACCTATCGACGGCGCGCCACCGCAGCGGGGCAGTC
GCTGCAGACGTATATGCGCACCAAGCTCATCGAAGGGGTGCGGGGCCGAGACAAGGCCGAGGTAATCGAGATCCTGGAAC
AGGCGCTCGCCAGCACTGCCAGCCCAGGCATCAGCCGGGAGACCATCGAGGCATCCCGGCGGGAGCTCAGGGGTGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U4JRE1

Antitoxin

Source ID Structure
AlphaFold DB A0A0U4HY11

References