Detailed information of TA system TA198360

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelE-RHH
• Location: 1243489..1244036
• Replicon: chromosome
• Accession: NZ_CP072742
• Organism: Serratia fonticola strain R28

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: J8M99_RS05795
• Protein ID: WP_245398412.1
• Coordinates: 1243489..1243767 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A7Y8XL57
• Locus tag: J8M99_RS05800
• Protein ID: WP_059201942.1
• Coordinates: 1243767..1244036 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J8M99_RS05775 (J8M99_05770)	1238692..1238955	+	264	WP_021179031.1	peroxide/acid stress response protein YhcN	-
J8M99_RS05780 (J8M99_05775)	1239168..1240547	-	1380	WP_024483358.1	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase	-
J8M99_RS05785 (J8M99_05780)	1240718..1241722	+	1005	WP_021179030.1	class 1 fructose-bisphosphatase	-
J8M99_RS05790 (J8M99_05785)	1241758..1243311	-	1554	WP_021807532.1	methyl-accepting chemotaxis protein	-
J8M99_RS05795 (J8M99_05790)	1243489..1243767	-	279	WP_245398412.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
J8M99_RS05800 (J8M99_05795)	1243767..1244036	-	270	WP_059201942.1	hypothetical protein	Antitoxin
J8M99_RS05805 (J8M99_05800)	1244225..1244752	+	528	WP_021179028.1	inorganic diphosphatase	-
J8M99_RS05810 (J8M99_05805)	1244803..1245153	-	351	WP_024483355.1	gamma-glutamylcyclotransferase	-
J8M99_RS05815 (J8M99_05810)	1245156..1248980	-	3825	WP_218519944.1	translocation/assembly module TamB domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10984.56 Da
• Isoelectric Point: 6.4886

>T198360 WP_245398412.1 NZ_CP072742:c1243767-1243489 [Serratia fonticola]
MEIVWTQLASEDRRKIREYIAENNLRAAIELDERIGSMANSLAEHPLKGREGRVKETRELVIHPHFIEVYRVVNEWERIE
IIRVLHTAQQWP

Nucleotide

• Length: 279 bp

>T198360 NZ_CP096845:c3655343-3654915 [Mycobacterium tuberculosis variant bovis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9950.18 Da
• Isoelectric Point: 5.8375

>AT198360 WP_059201942.1 NZ_CP072742:c1244036-1243767 [Serratia fonticola]
MTQTTLNLRIDTELKTDFLEAAKAMDRNGSQLIRDFMRETVQRQHDIWFRDQVQAGIAQANRGEVLSGESVEASAVAWRE
AAAKKLAGS

Nucleotide

• Length: 270 bp

>AT198360 NZ_CP096845:c3655589-3655347 [Mycobacterium tuberculosis variant bovis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Structures

Antitoxin

• AlphaFold DB: A0A7Y8XL57