Detailed information of TA system TA198359

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/-
• Location: 1178751..1179253
• Replicon: chromosome
• Accession: NZ_CP072742
• Organism: Serratia fonticola strain R28

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: J8M99_RS05450
• Protein ID: WP_218519933.1
• Coordinates: 1178751..1178957 (-)
• Length: 69 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U2NJB3
• Locus tag: J8M99_RS05455
• Protein ID: WP_021179086.1
• Coordinates: 1178966..1179253 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J8M99_RS05430 (J8M99_05425)	1175961..1176425	+	465	WP_021807485.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
J8M99_RS05435 (J8M99_05430)	1176431..1176703	-	273	Protein_1058	tyrosine-type recombinase/integrase	-
J8M99_RS05440 (J8M99_05435)	1177175..1177882	+	708	WP_094981867.1	hypothetical protein	-
J8M99_RS05445 (J8M99_05440)	1178138..1178614	-	477	WP_094981869.1	Hcp family type VI secretion system effector	-
J8M99_RS05450 (J8M99_05445)	1178751..1178957	-	207	WP_218519933.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
J8M99_RS05455 (J8M99_05450)	1178966..1179253	-	288	WP_021179086.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
J8M99_RS05460 (J8M99_05455)	1179543..1180271	+	729	WP_094981871.1	phosphonate metabolism transcriptional regulator PhnF	-
J8M99_RS05465 (J8M99_05460)	1180272..1180715	+	444	WP_059199561.1	phosphonate C-P lyase system protein PhnG	-
J8M99_RS05470 (J8M99_05465)	1180719..1181300	+	582	WP_059199560.1	phosphonate C-P lyase system protein PhnH	-
J8M99_RS05475 (J8M99_05470)	1181300..1182385	+	1086	WP_021807490.1	carbon-phosphorus lyase complex subunit PhnI	-
J8M99_RS05480 (J8M99_05475)	1182378..1183229	+	852	WP_021807491.1	alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase PhnJ	-
J8M99_RS05485 (J8M99_05480)	1183229..1184017	+	789	WP_218519934.1	phosphonate C-P lyase system protein PhnK	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-51)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-44)

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7852.87 Da
• Isoelectric Point: 3.8209

>T198359 WP_218519933.1 NZ_CP072742:c1178957-1178751 [Serratia fonticola]
MRIEWDDVALQDRERIFEFLFPLNPLAAEQVDDEIELAVESLLENPEMGRLTSLASFVSAQLFNNKNI

Nucleotide

• Length: 207 bp

>T198359 NZ_CP096845:3500427-3500771 [Mycobacterium tuberculosis variant bovis]
TTGGCCGTGATCCTGCTCCCGCAGGTCGAACGGTGGTTCTTCGCGCTCAACAGGGATGCGATGGCCTCGGTCACCGGCGC
CATCGACCTGCTCGAAATGGAGGGGCCGACGTTGGGCCGCCCGGTGGTCGACAAAGTGAACGACTCAACGTTTCACAACA
TGAAGGAGCTGCGCCCCGCCGGCACCAGCATCCGGATCCTGTTCGCCTTCGACCCGGCCCGGCAGGCGATCCTGCTGCTG
GGCGGTGACAAGGCAGGCAACTGGAAACGCTGGTACGACAACAACATTCCAATCGCTGACCAGCGCTCCGAGAACTGGCT
GGCGAGCGAGCACGGAGGTGGATGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10957.35 Da
• Isoelectric Point: 8.0314

>AT198359 WP_021179086.1 NZ_CP072742:c1179253-1178966 [Serratia fonticola]
MESRIQFRIENETKLLAQKAAEAKGTTLSEACRRLAQQMADDQRAAEEHENWLKDKVDAAFARLHEGEAVYLTQRQAEER
MSDFKAKVRAKYATK

Nucleotide

• Length: 288 bp

>AT198359 NZ_CP096845:3500768-3501097 [Mycobacterium tuberculosis variant bovis]
ATGACCATGGCCCGCAACTGGCGTGACATTCGCGCCGATGCCGTCGCGCAGGGCCGCGTGGATCTGCAGCGGGCCGCCGT
GGCACGCGAGGAGATGCGCGATGCCGTCCTGGCGCACCGCCTGGCCGAGATCCGCAAGGCGCTAGGCCACGCACGTCAGG
CCGACGTCGCGGCGCTGATGGGGGTCTCTCAGGCCCGTGTCTCCAAGCTGGAGAGCGGCGACCTGTCCCACACCGAACTC
GGCACCCTGCAGGCCTACGTTGCCGCCCTGGGCGGGCACCTGCGCATCGTCGCTGAGTTCGGCGAAAATACTGTCGAGCT
GACCGCCTGA

Structures

Antitoxin

• AlphaFold DB: U2NJB3