Detailed information of TA system TA198357

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 615229..615785
• Replicon: chromosome
• Accession: NZ_CP072742
• Organism: Serratia fonticola strain R28

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: J8M99_RS02980
• Protein ID: WP_021805609.1
• Coordinates: 615495..615785 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U2MX00
• Locus tag: J8M99_RS02975
• Protein ID: WP_021181943.1
• Coordinates: 615229..615507 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J8M99_RS02955 (J8M99_02950)	610755..611528	+	774	WP_021805606.1	amidohydrolase	-
J8M99_RS02960 (J8M99_02955)	611471..612790	-	1320	Protein_578	allantoate amidohydrolase	-
J8M99_RS02965 (J8M99_02960)	612790..614031	-	1242	WP_218519809.1	alanine--glyoxylate aminotransferase family protein	-
J8M99_RS02970 (J8M99_02965)	614223..615062	-	840	WP_021181942.1	MurR/RpiR family transcriptional regulator	-
J8M99_RS02975 (J8M99_02970)	615229..615507	+	279	WP_021181943.1	CopG family ribbon-helix-helix protein	Antitoxin
J8M99_RS02980 (J8M99_02975)	615495..615785	+	291	WP_021805609.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
J8M99_RS02985 (J8M99_02980)	615782..616660	-	879	WP_218519810.1	siderophore-interacting protein	-
J8M99_RS02990 (J8M99_02985)	616662..617888	-	1227	WP_094983019.1	MFS transporter	-
J8M99_RS02995 (J8M99_02990)	618022..619752	+	1731	WP_094983018.1	IucA/IucC family protein	-
J8M99_RS03000 (J8M99_02995)	619749..620699	+	951	WP_218519811.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10910.59 Da
• Isoelectric Point: 9.3939

>T198357 WP_021805609.1 NZ_CP072742:615495-615785 [Serratia fonticola]
VSQLKWSPAALADVQRLYLFLAEKDSDTAKRAISKIRRSVKILALQPQVGRPVEEMPHQYREWPIEFGSSGYVVLYHFDG
TVAVLLAVRHQLEAGY

Nucleotide

• Length: 291 bp

>T198357 NZ_CP096845:3126020-3126283 [Mycobacterium tuberculosis variant bovis]
GTGCCTTACACCGTGCGGTTCACCACAACCGCGCGTCGAGACCTCCACAAGCTGCCACCGCGAATCCTCGCGGCAGTGGT
CGAATTCGCGTTCGGCGATCTGTCGCGCGAGCCCCTGCGGGTGGGCAAGCCCCTTCGGCGCGAGTTGGCCGGCACGTTCA
GCGCGCGTCGCGGAACGTACCGCCTGCTGTACCGGATTGACGACGAGCACACAACGGTAGTGATCCTGCGCGTCGATCAC
CGCGCGGACATCTACCGCCGATAG

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10862.10 Da
• Isoelectric Point: 4.7997

>AT198357 WP_021181943.1 NZ_CP072742:615229-615507 [Serratia fonticola]
MATATSIKIDEELKLRVQQIALARQRTAHWIMREAIREYVEREEKREALRNDALRAWETYQADGKHLTQEEADNWLANLE
KGDDTEIPECHN

Nucleotide

• Length: 279 bp

>AT198357 NZ_CP096845:3125735-3126016 [Mycobacterium tuberculosis variant bovis]
ATGCGGATACTGCCGATTTCGACGATCAAGGGCAAGCTCAATGAGTTCGTCGACGCGGTCTCGTCGACACAGGACCAGAT
CACCATCACCAAGAACGGTGCACCCGCAGCCGTTCTGGTCGGCGCCGACGAGTGGGAATCGTTGCAGGAGACGCTGTACT
GGCTGGCGCAACCCGGAATCAGGGAGTCGATCGCTGAAGCCGACGCCGACATTGCCTCCGGCCGCACCTACGGCGAAGAC
GAGATCCGCGCCGAATTCGGCGTCCCGCGACGCCCCCACTGA

Structures

Antitoxin

• AlphaFold DB: U2MX00