Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 385314..385962 Replicon chromosome
Accession NZ_CP072742
Organism Serratia fonticola strain R28

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag J8M99_RS01915 Protein ID WP_094981177.1
Coordinates 385314..385517 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U2LL75
Locus tag J8M99_RS01920 Protein ID WP_021180099.1
Coordinates 385555..385962 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8M99_RS01885 (J8M99_01880) 380490..381305 - 816 WP_218519769.1 HTH-type transcriptional repressor AllR -
J8M99_RS01890 (J8M99_01885) 381375..381866 - 492 WP_059201975.1 ureidoglycolate lyase -
J8M99_RS01895 (J8M99_01890) 382219..383142 + 924 WP_021180095.1 HTH-type transcriptional activator AllS -
J8M99_RS01900 (J8M99_01895) 383326..384231 + 906 WP_021180096.1 SPFH domain-containing protein -
J8M99_RS01905 (J8M99_01900) 384234..384692 + 459 WP_094981175.1 NfeD family protein -
J8M99_RS01910 (J8M99_01905) 384689..385090 - 402 WP_094981176.1 Cu(I)-responsive transcriptional regulator -
J8M99_RS01915 (J8M99_01910) 385314..385517 + 204 WP_094981177.1 type II toxin-antitoxin system HicA family toxin Toxin
J8M99_RS01920 (J8M99_01915) 385555..385962 + 408 WP_021180099.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
J8M99_RS01925 (J8M99_01920) 386226..388937 + 2712 WP_218519770.1 copper-exporting P-type ATPase CopA -
J8M99_RS01930 (J8M99_01925) 389087..389890 + 804 WP_218519771.1 TraB/GumN family protein -
J8M99_RS01935 (J8M99_01930) 390112..390591 + 480 WP_094981179.1 Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 7370.83 Da        Isoelectric Point: 11.5784

>T198355 WP_094981177.1 NZ_CP072742:385314-385517 [Serratia fonticola]
MESGELIKRLQADGWIIRKSRGKKATGSHVTMTKPGVAKIITIPHPKKDPSKGILRQVQQISGLKLI

Download         Length: 204 bp

>T198355 NZ_CP096845:c3082899-3082015 [Mycobacterium tuberculosis variant bovis]
GTGGCCGGTCTGACCCGTGCGCTCGTTGCGCGTCACGCTCTTGGTCGGGCCGAGGCATACGACGCCGCTCTGCTCGACGT
CGCCCAGGACCACCTGCTGTACCTGCTGTCGCAGACCGTCCAGTTCGGCGATAACCGCCTGGTGTTCAAAGGCGGTACCA
GCTTACGGAAGTGCCGGCTGGGCAACGTCGGGCGGTTCTCCACTGATCTGGACTTCAGCGCGCCCGACGATGAGGTCGTG
CTGGAGGTGTGCGAGCTGATCGACGGCGCCCGTGTCGGCGGCTTCGAATTCGGCGTGCAGAGCACACGAGGCGACGGCCG
GCATTGGCAGTTGCGGGTGCGGCACACGGAATTGGGCGAGCCCCGGATCGTCGCCAGCGTCGAGTTCGCACGGCGGCCGT
TGGCTTTGCCGTCTGAGCTGCTCGCATTCATCCAGTTGCCGATCCATAAGGCTTACGGTTTTGGGCTGCCGACACTGCCG
GTCGTGGCAGAAGCGGAAGCCTGCGCAGAGAAACTCGCGCGGTACCGCCGCGTTGCGCTGGCACGGGACCTGTACGACCT
GAACCACTTCGCCTCGCGAACGATTGACGAACCGCTCGTGCGGCGGCTGTGGGTGCTCAAGGTGTGGGGTGATGTCGTCG
ATGACCGGCGCGGCACCCGGCCACTACGCGTCGAAGACGTCCTCGCCGCCCGCAGCGAGCACGACTTCCAGCCCGACTCG
ATCGGCGTGCTGACCCGTCCTGTCGCTATGGCTGCCTGGGAAGCTCGCGTTCGGAAGCGATTTGCGTTCCTCACTGACCT
CGACGCCGACGAGCAGCGGTGGGCCGCCTGCGACGAACGGCACCGCCGCGAAGTGGAGAACGCGCTGGCGGTGCTGCGGT
CCTGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 15337.37 Da        Isoelectric Point: 4.4886

>AT198355 WP_021180099.1 NZ_CP072742:385555-385962 [Serratia fonticola]
MIYPIFIFKTSEGFDGYFPDVEGCFFAGEKMSDIPKNAEEAFGVHMEALIEEGFPVPAAPQDPQSYLNDSRLREDGGILG
FVEIDPAKYEDKSIKFNLTMPRNLLTAIDKYIETTRGYKNRSQFLAELAREKISH

Download         Length: 408 bp

>AT198355 NZ_CP096845:c3083789-3082902 [Mycobacterium tuberculosis variant bovis]
GTGGTGAGCCCAGCCGGCGCCGATCGGCGCATCCCCACGTGGGCGTCACGGGTGGTGTCCGGCCTCGCTCGCGATCGGCC
CGTAGTCGTCACGAAAGAGGATCTGACGCAACGGCTTACAGAGGCTGGGTGTGGACGCGACCCCGACTCCGCCATCCGCG
AACTGCGCCGCATTGGGTGGCTGGTCCAACTGCCGGTGAAAGGCACCTGGGCATTCATTCCCCCCGGCGAGGCCGCCATC
TCGGACCCGTATCTACCGCTGCGCTCGTGGCTGGCCCGTGACCAGAACGCGGGCTTCATGCTGGCCGGTGCATCCGCAGC
GTGGCACCTCGGATACCTGGACCGCCAACCCGACGGCCGCATCCCGATCTGGCTGCCGCCGGCCAAAAGGCTGCCCGACG
GCCTAGCATCGTATGTGTCCGTCGTGCGCATCCCCTGGAACGCGGCGGACACCGCACTGCTGGCTCCGCGTCCCGCGTTG
CTGGTCCGGCGGCGGCTCGACCTCGTCGCGTGGGCGACCGGGTTACCGGCGCTAGGACCAGAAGCATTACTTGTGCAAAT
CGCCACGCGCCCGGCCTCGTTCGGGCCGTGGGCCGACCTTGTCCCCCACCTTGACGACCTCGTCGCCGACTGCAGTGACG
AGCGTCTGGAGCGTCTACTGTCGGGCCGGCCGACATCGGCCTGGCAGCGTGCAAGCTACCTGCTGGACTCGGGCGGTGAA
CCGGCACGAGGCCAGGCGCTGCTGGCCAAGCGGCACACCGAAGTGATGCCGGTGACTCGATTCACCACCGCGCACAGCCG
CGACCGTGGCGAGAGTGTCTGGGCTCCCGAGTATCAGCTTGTCGACGAGCTCGTCGTACCGCTGCTGCGCGTGATCGGCA
AGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB U2LL75

References