Detailed information of TA system TA198355

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 385314..385962
• Replicon: chromosome
• Accession: NZ_CP072742
• Organism: Serratia fonticola strain R28

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: J8M99_RS01915
• Protein ID: WP_094981177.1
• Coordinates: 385314..385517 (+)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: U2LL75
• Locus tag: J8M99_RS01920
• Protein ID: WP_021180099.1
• Coordinates: 385555..385962 (+)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J8M99_RS01885 (J8M99_01880)	380490..381305	-	816	WP_218519769.1	HTH-type transcriptional repressor AllR	-
J8M99_RS01890 (J8M99_01885)	381375..381866	-	492	WP_059201975.1	ureidoglycolate lyase	-
J8M99_RS01895 (J8M99_01890)	382219..383142	+	924	WP_021180095.1	HTH-type transcriptional activator AllS	-
J8M99_RS01900 (J8M99_01895)	383326..384231	+	906	WP_021180096.1	SPFH domain-containing protein	-
J8M99_RS01905 (J8M99_01900)	384234..384692	+	459	WP_094981175.1	NfeD family protein	-
J8M99_RS01910 (J8M99_01905)	384689..385090	-	402	WP_094981176.1	Cu(I)-responsive transcriptional regulator	-
J8M99_RS01915 (J8M99_01910)	385314..385517	+	204	WP_094981177.1	type II toxin-antitoxin system HicA family toxin	Toxin
J8M99_RS01920 (J8M99_01915)	385555..385962	+	408	WP_021180099.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
J8M99_RS01925 (J8M99_01920)	386226..388937	+	2712	WP_218519770.1	copper-exporting P-type ATPase CopA	-
J8M99_RS01930 (J8M99_01925)	389087..389890	+	804	WP_218519771.1	TraB/GumN family protein	-
J8M99_RS01935 (J8M99_01930)	390112..390591	+	480	WP_094981179.1	Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 7370.83 Da
• Isoelectric Point: 11.5784

>T198355 WP_094981177.1 NZ_CP072742:385314-385517 [Serratia fonticola]
MESGELIKRLQADGWIIRKSRGKKATGSHVTMTKPGVAKIITIPHPKKDPSKGILRQVQQISGLKLI

Nucleotide

• Length: 204 bp

>T198355 NZ_CP096845:c3082899-3082015 [Mycobacterium tuberculosis variant bovis]
GTGGCCGGTCTGACCCGTGCGCTCGTTGCGCGTCACGCTCTTGGTCGGGCCGAGGCATACGACGCCGCTCTGCTCGACGT
CGCCCAGGACCACCTGCTGTACCTGCTGTCGCAGACCGTCCAGTTCGGCGATAACCGCCTGGTGTTCAAAGGCGGTACCA
GCTTACGGAAGTGCCGGCTGGGCAACGTCGGGCGGTTCTCCACTGATCTGGACTTCAGCGCGCCCGACGATGAGGTCGTG
CTGGAGGTGTGCGAGCTGATCGACGGCGCCCGTGTCGGCGGCTTCGAATTCGGCGTGCAGAGCACACGAGGCGACGGCCG
GCATTGGCAGTTGCGGGTGCGGCACACGGAATTGGGCGAGCCCCGGATCGTCGCCAGCGTCGAGTTCGCACGGCGGCCGT
TGGCTTTGCCGTCTGAGCTGCTCGCATTCATCCAGTTGCCGATCCATAAGGCTTACGGTTTTGGGCTGCCGACACTGCCG
GTCGTGGCAGAAGCGGAAGCCTGCGCAGAGAAACTCGCGCGGTACCGCCGCGTTGCGCTGGCACGGGACCTGTACGACCT
GAACCACTTCGCCTCGCGAACGATTGACGAACCGCTCGTGCGGCGGCTGTGGGTGCTCAAGGTGTGGGGTGATGTCGTCG
ATGACCGGCGCGGCACCCGGCCACTACGCGTCGAAGACGTCCTCGCCGCCCGCAGCGAGCACGACTTCCAGCCCGACTCG
ATCGGCGTGCTGACCCGTCCTGTCGCTATGGCTGCCTGGGAAGCTCGCGTTCGGAAGCGATTTGCGTTCCTCACTGACCT
CGACGCCGACGAGCAGCGGTGGGCCGCCTGCGACGAACGGCACCGCCGCGAAGTGGAGAACGCGCTGGCGGTGCTGCGGT
CCTGA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 15337.37 Da
• Isoelectric Point: 4.4886

>AT198355 WP_021180099.1 NZ_CP072742:385555-385962 [Serratia fonticola]
MIYPIFIFKTSEGFDGYFPDVEGCFFAGEKMSDIPKNAEEAFGVHMEALIEEGFPVPAAPQDPQSYLNDSRLREDGGILG
FVEIDPAKYEDKSIKFNLTMPRNLLTAIDKYIETTRGYKNRSQFLAELAREKISH

Nucleotide

• Length: 408 bp

>AT198355 NZ_CP096845:c3083789-3082902 [Mycobacterium tuberculosis variant bovis]
GTGGTGAGCCCAGCCGGCGCCGATCGGCGCATCCCCACGTGGGCGTCACGGGTGGTGTCCGGCCTCGCTCGCGATCGGCC
CGTAGTCGTCACGAAAGAGGATCTGACGCAACGGCTTACAGAGGCTGGGTGTGGACGCGACCCCGACTCCGCCATCCGCG
AACTGCGCCGCATTGGGTGGCTGGTCCAACTGCCGGTGAAAGGCACCTGGGCATTCATTCCCCCCGGCGAGGCCGCCATC
TCGGACCCGTATCTACCGCTGCGCTCGTGGCTGGCCCGTGACCAGAACGCGGGCTTCATGCTGGCCGGTGCATCCGCAGC
GTGGCACCTCGGATACCTGGACCGCCAACCCGACGGCCGCATCCCGATCTGGCTGCCGCCGGCCAAAAGGCTGCCCGACG
GCCTAGCATCGTATGTGTCCGTCGTGCGCATCCCCTGGAACGCGGCGGACACCGCACTGCTGGCTCCGCGTCCCGCGTTG
CTGGTCCGGCGGCGGCTCGACCTCGTCGCGTGGGCGACCGGGTTACCGGCGCTAGGACCAGAAGCATTACTTGTGCAAAT
CGCCACGCGCCCGGCCTCGTTCGGGCCGTGGGCCGACCTTGTCCCCCACCTTGACGACCTCGTCGCCGACTGCAGTGACG
AGCGTCTGGAGCGTCTACTGTCGGGCCGGCCGACATCGGCCTGGCAGCGTGCAAGCTACCTGCTGGACTCGGGCGGTGAA
CCGGCACGAGGCCAGGCGCTGCTGGCCAAGCGGCACACCGAAGTGATGCCGGTGACTCGATTCACCACCGCGCACAGCCG
CGACCGTGGCGAGAGTGTCTGGGCTCCCGAGTATCAGCTTGTCGACGAGCTCGTCGTACCGCTGCTGCGCGTGATCGGCA
AGGCGTGA

Structures

Antitoxin

• AlphaFold DB: U2LL75