Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 18210..18729 Replicon plasmid pVB3378_p1
Accession NZ_CP072708
Organism Enterococcus faecium strain VB3378

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag J7155_RS13580 Protein ID WP_000588503.1
Coordinates 18472..18729 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag J7155_RS13575 Protein ID WP_000388479.1
Coordinates 18210..18479 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J7155_RS13530 (J7155_13510) 13407..14306 + 900 WP_002303312.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
J7155_RS13535 (J7155_13515) 14309..14794 + 486 WP_002303313.1 single-stranded DNA-binding protein -
J7155_RS16000 14935..15039 - 105 WP_008274030.1 putative holin-like toxin -
J7155_RS13545 (J7155_13525) 15213..15473 + 261 WP_002295623.1 hypothetical protein -
J7155_RS13550 (J7155_13530) 15910..16116 + 207 WP_002347218.1 hypothetical protein -
J7155_RS13555 (J7155_13535) 16116..16367 + 252 WP_002296238.1 hypothetical protein -
J7155_RS13560 (J7155_13540) 16382..16819 + 438 WP_002300851.1 hypothetical protein -
J7155_RS13565 (J7155_13545) 16812..17519 + 708 WP_002303117.1 hypothetical protein -
J7155_RS16005 17684..17884 + 201 WP_002347143.1 hypothetical protein -
J7155_RS13570 (J7155_13550) 17900..18079 + 180 WP_001120991.1 hypothetical protein -
J7155_RS13575 (J7155_13555) 18210..18479 + 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
J7155_RS13580 (J7155_13560) 18472..18729 + 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
J7155_RS13585 (J7155_13565) 19188..19343 + 156 WP_002347142.1 hypothetical protein -
J7155_RS13590 (J7155_13570) 19367..20191 + 825 WP_001809248.1 hypothetical protein -
J7155_RS13595 (J7155_13575) 20356..20970 - 615 WP_001261742.1 recombinase family protein -
J7155_RS13600 (J7155_13580) 21208..21630 + 423 WP_002303116.1 hypothetical protein -
J7155_RS13605 (J7155_13585) 21640..21843 + 204 WP_002299573.1 hypothetical protein -
J7155_RS13610 (J7155_13590) 22054..22638 + 585 WP_002299575.1 recombinase family protein -
J7155_RS13615 (J7155_13595) 22827..23507 - 681 WP_010861579.1 IS6-like element IS1216 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aac(6')-aph(2'') - 1..227172 227172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T198341 WP_000588503.1 NZ_CP072708:18472-18729 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T198341 NZ_CP096845:c2207713-2207153 [Mycobacterium tuberculosis variant bovis]
GTGAGCGATGCCCTCGATGAAGGGCTCGTCCAGCGTATCGACGCACGCGGAACAATTGAGTGGTCGGAAACGTGCTACCG
GTATACCGGCGCGCACCGTGACGCCTTGTCCGGTGAGGGCGCGCGCAGATTCGGAGGCAGGTGGAATCCGCCGCTGCTCT
TTCCGGCGATCTATCTTGCTGATTCCGCCCAAGCCTGCATGGTTGAGGTGGAACGGGCGGCGCAAGCGGCTTCAACGACC
GCAGAGAAGATGCTCGAGGCGGCCTACCGACTACACACGATCGACGTCACGGACCTGGCCGTCCTCGATCTGACAACCCC
GCAAGCTCGGGAAGCCGTGGGGCTCGAGAACGACGACATCTATGGCGACGACTGGTCAGGGTGCCAGGCGGTCGGACATG
CGGCCTGGTTCTTGCACATGCAAGGTGTCCTCGTGCCGGCGGCGGGCGGTGTCGGCCTCGTTGTCACCGCGTATGAACAG
CGAACTCGGCCGGGCCAACTACAACTGCGACAAAGCGTCGATCTGACGCCTGCTCTTTACCAAGAACTTCGAGCCACGTA
G

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT198341 WP_000388479.1 NZ_CP072708:18210-18479 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT198341 NZ_CP096845:c2208051-2207710 [Mycobacterium tuberculosis variant bovis]
ATGGGAGTAAATGTGCTCGCCTCGACCGTGTCGGGTGCGATCGAGCGCTTGGGATTGACCTACGAGGAAGTCGGTGACAT
CGTCGATGCCTCGCCGCGTTCCGTGGCGCGATGGACCGCAGGTCAGGTGGTTCCCCAACGCCTCAACAAGCAACGACTTA
TCGAGCTGGCCTATGTCGCCGACGCCCTCGCGGAAGTGCTGCCGCGTGACCAGGCGAACGTGTGGATGTTTTCGCCGAAT
CGGTTACTGGAACACCGCAAGCCTGCCGACCTCGTGCGAGACGGCGAGTACCAACGCGTGTTGGCGCTCATCGACGCGAT
GGCGGAGGGAGTGTTCGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References