Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relE-yefM/Txe-RelB |
Location | 1478428..1478957 | Replicon | chromosome |
Accession | NZ_CP072707 | ||
Organism | Enterococcus faecium strain VB3378 |
Toxin (Protein)
Gene name | relE | Uniprot ID | Q3XX67 |
Locus tag | J7155_RS07095 | Protein ID | WP_002296560.1 |
Coordinates | 1478691..1478957 (+) | Length | 89 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | A0A829F3T0 |
Locus tag | J7155_RS07090 | Protein ID | WP_002296559.1 |
Coordinates | 1478428..1478691 (+) | Length | 88 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
J7155_RS07080 (J7155_07065) | 1475802..1477625 | + | 1824 | WP_002294202.1 | APC family permease | - |
J7155_RS07085 (J7155_07070) | 1477767..1477952 | - | 186 | WP_002296558.1 | transcriptional regulator | - |
J7155_RS07090 (J7155_07075) | 1478428..1478691 | + | 264 | WP_002296559.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
J7155_RS07095 (J7155_07080) | 1478691..1478957 | + | 267 | WP_002296560.1 | Txe/YoeB family addiction module toxin | Toxin |
J7155_RS07100 (J7155_07085) | 1479158..1479646 | + | 489 | WP_002296561.1 | mannosyl-glycoprotein endo-beta-N-acetylglucosamidase | - |
J7155_RS07105 (J7155_07090) | 1480187..1480858 | - | 672 | WP_002302663.1 | ABC transporter permease | - |
J7155_RS07110 (J7155_07095) | 1480855..1481772 | - | 918 | WP_002296564.1 | osmoprotectant ABC transporter substrate-binding protein | - |
J7155_RS07115 (J7155_07100) | 1481769..1482410 | - | 642 | WP_002293405.1 | ABC transporter permease | - |
J7155_RS07120 (J7155_07105) | 1482414..1483589 | - | 1176 | WP_002294192.1 | betaine/proline/choline family ABC transporter ATP-binding protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10660.13 Da Isoelectric Point: 9.9931
>T198339 WP_002296560.1 NZ_CP072707:1478691-1478957 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQTNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE
MSNYTVAIKNSAKVDLRKIKQTNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE
Download Length: 267 bp
>T198339 NZ_CP096845:c2191110-2190814 [Mycobacterium tuberculosis variant bovis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
Antitoxin
Download Length: 88 a.a. Molecular weight: 10046.05 Da Isoelectric Point: 4.1207
>AT198339 WP_002296559.1 NZ_CP072707:1478428-1478691 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSSFTNID
DIDWEAL
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSSFTNID
DIDWEAL
Download Length: 264 bp
>AT198339 NZ_CP096845:c2191358-2191107 [Mycobacterium tuberculosis variant bovis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829FCW8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829F3T0 |