Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataT-KacA/DUF1778(antitoxin)
Location 33655..34453 Replicon plasmid unnamed1
Accession NZ_CP072690
Organism Escherichia marmotae strain YF8

Toxin (Protein)


Gene name ataT Uniprot ID A0A141BRA1
Locus tag J8I93_RS21885 Protein ID WP_063277812.1
Coordinates 33932..34453 (+) Length 174 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID A0A141BRA2
Locus tag J8I93_RS21880 Protein ID WP_001711191.1
Coordinates 33655..33924 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8I93_RS21855 (J8I93_21615) 29081..30421 - 1341 WP_000137333.1 DnaB-like helicase C-terminal domain-containing protein -
J8I93_RS21860 (J8I93_21620) 30465..31205 - 741 WP_001717320.1 hypothetical protein -
J8I93_RS21865 (J8I93_21625) 31488..32255 + 768 WP_128111716.1 hypothetical protein -
J8I93_RS21870 (J8I93_21630) 32308..32661 - 354 WP_160378290.1 hypothetical protein -
J8I93_RS21875 (J8I93_21635) 32667..33335 - 669 WP_000161228.1 division plane positioning ATPase MipZ -
J8I93_RS21880 (J8I93_21640) 33655..33924 + 270 WP_001711191.1 DUF1778 domain-containing protein Antitoxin
J8I93_RS21885 (J8I93_21645) 33932..34453 + 522 WP_063277812.1 GNAT family N-acetyltransferase Toxin
J8I93_RS21890 (J8I93_21650) 34622..34873 - 252 WP_142440213.1 hypothetical protein -
J8I93_RS21895 (J8I93_21655) 34875..35567 - 693 WP_000856757.1 hypothetical protein -
J8I93_RS21900 (J8I93_21660) 35581..35904 - 324 WP_001717323.1 hypothetical protein -
J8I93_RS21905 (J8I93_21665) 36086..36370 - 285 WP_112864249.1 hypothetical protein -
J8I93_RS21910 (J8I93_21670) 36381..37085 - 705 WP_282502975.1 tail fiber domain-containing protein -
J8I93_RS21915 (J8I93_21675) 37098..37367 - 270 WP_001544317.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..110685 110685


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19420.23 Da        Isoelectric Point: 8.6369

>T198332 WP_063277812.1 NZ_CP072690:33932-34453 [Escherichia marmotae]
VSNTTIEIFSGEKDYDLNGFDCGEESLNAFLVNHLKRQHEGKILRAYVLCTQEERPKVLGYYTLSGSCFEKESLPSRSKQ
KKVPYRNVPSVTLGRLALDKSLQGQGFGSMLVTHAMRVVYNASLAVGIHGLFVEALNDKAKAFYKSLGFIQLVGNNERSL
FYPTKSIEKLFEE

Download         Length: 522 bp

>T198332 NZ_CP096845:c1567585-1567184 [Mycobacterium tuberculosis variant bovis]
ATGATCCTTGTCGACTCCGATGTGCTGATCGCGCATTTGCGGGGTGTCGTTGCTGCTCGCGATTGGCTTGTCAGCGCCCG
CAAGGACGGACCGCTGGCGATCAGCGTGGTGTCCACCGCCGAACTCATCGGCGGAATGCGGACCGCCGAACGGCGCGAGG
TGTGGCGCCTGCTTGCATCGTTTCGGGTACAGCCAGCAACCGAGGTAATCGCACGCCGCGCCGGCGACATGATGCGCCGA
TATCGTCGCAGCCACAACCGGATTGGACTTGGCGACTATCTGATAGCTGCTACCGCCGACGTCCAGGGCCTGCAATTGGC
AACCCTCAACGTGTGGCATTTCCCCATGTTCGAGCAGCTGAAACCACCATTTGCGGTGCCGGGGCACCGACCGCGGGCAT
GA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10054.53 Da        Isoelectric Point: 8.7353

>AT198332 WP_001711191.1 NZ_CP072690:33655-33924 [Escherichia marmotae]
MSALKKQRIDLRLTDDDKSIIEEAAAMSNQSITQFMVSSASERAVKVIEQHRRLVLSEESWNLVMDAISNPPAPNDKLKR
AANRLKSME

Download         Length: 270 bp

>AT198332 NZ_CP096845:c1567839-1567582 [Mycobacterium tuberculosis variant bovis]
ATGAAGCGGACCAACATCTACCTCGACGAGGAGCAGACGGCAAGCCTCGACAAGTTGGCCGCGCAAGAAGGTGTTTCGCG
CGCCGAGCTGATCCGCCTCCTGCTGAACCGAGCCCTCACCACCGCTGGGGACGACCTTGCATCGGACCTGCAGGCTATAA
ACGATTCGTTCGGCACGCTTCGCCACCTGGATCCGCCGGTGCGTCGCTCCGGTGGTCGTGAACAGCACCTTGCCCAGGTG
TGGCGCGCCACCTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A141BRA1

Antitoxin

Source ID Structure
AlphaFold DB A0A141BRA2

References