Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1155672..1156290 Replicon chromosome
Accession NZ_CP072689
Organism Escherichia marmotae strain YF8

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag J8I93_RS05300 Protein ID WP_001280991.1
Coordinates 1155672..1155890 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A7U9DNY0
Locus tag J8I93_RS05305 Protein ID WP_000344801.1
Coordinates 1155895..1156290 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8I93_RS05265 (1150966) 1150966..1151538 + 573 WP_000779815.1 YbaY family lipoprotein -
J8I93_RS05270 (1151569) 1151569..1151880 - 312 WP_000409903.1 MGMT family protein -
J8I93_RS05280 (1152260) 1152260..1152613 + 354 WP_000878149.1 DUF1428 domain-containing protein -
J8I93_RS05285 (1152650) 1152650..1154200 - 1551 WP_001515896.1 EAL domain-containing protein -
J8I93_RS05290 (1154364) 1154364..1154834 - 471 WP_001515897.1 YlaC family protein -
J8I93_RS05295 (1154949) 1154949..1155500 - 552 WP_000102537.1 maltose O-acetyltransferase -
J8I93_RS05300 (1155672) 1155672..1155890 - 219 WP_001280991.1 HHA domain-containing protein Toxin
J8I93_RS05305 (1155895) 1155895..1156290 - 396 WP_000344801.1 Hha toxicity modulator TomB Antitoxin
J8I93_RS05310 (1156847) 1156847..1159996 - 3150 WP_061090752.1 efflux RND transporter permease AcrB -
J8I93_RS05315 (1160019) 1160019..1161212 - 1194 WP_001515899.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T198316 WP_001280991.1 NZ_CP072689:c1155890-1155672 [Escherichia marmotae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T198316 NZ_CP096845:701231-701632 [Mycobacterium tuberculosis variant bovis]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 15393.22 Da        Isoelectric Point: 4.9228

>AT198316 WP_000344801.1 NZ_CP072689:c1156290-1155895 [Escherichia marmotae]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSCSNYYNHG

Download         Length: 396 bp

>AT198316 NZ_CP096845:700989-701234 [Mycobacterium tuberculosis variant bovis]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9DNY0

References