Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3064596..3065397 Replicon chromosome
Accession NZ_CP072688
Organism Escherichia coli strain P4

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H2V687
Locus tag J8I92_RS15120 Protein ID WP_000854739.1
Coordinates 3064596..3064976 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P7R0L9
Locus tag J8I92_RS15125 Protein ID WP_001285482.1
Coordinates 3065023..3065397 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8I92_RS15085 (3060188) 3060188..3060742 - 555 WP_001001921.1 molecular chaperone YcdY -
J8I92_RS15090 (3060766) 3060766..3061503 - 738 WP_000283664.1 zinc-binding phosphatase -
J8I92_RS15095 (3061558) 3061558..3062496 - 939 WP_000351277.1 glyoxylate/hydroxypyruvate reductase GhrA -
J8I92_RS15105 (3062966) 3062966..3063809 - 844 Protein_2967 DUF4942 domain-containing protein -
J8I92_RS15110 (3063894) 3063894..3064091 - 198 WP_000772027.1 DUF957 domain-containing protein -
J8I92_RS15115 (3064111) 3064111..3064599 - 489 WP_001518535.1 DUF5983 family protein -
J8I92_RS15120 (3064596) 3064596..3064976 - 381 WP_000854739.1 TA system toxin CbtA family protein Toxin
J8I92_RS15125 (3065023) 3065023..3065397 - 375 WP_001285482.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
J8I92_RS15130 (3065447) 3065447..3066091 - 645 WP_000086759.1 hypothetical protein -
J8I92_RS15135 (3066110) 3066110..3066331 - 222 WP_000692315.1 DUF987 domain-containing protein -
J8I92_RS15140 (3066394) 3066394..3066870 - 477 WP_001313574.1 RadC family protein -
J8I92_RS15145 (3066886) 3066886..3067359 - 474 WP_001313575.1 antirestriction protein -
J8I92_RS15150 (3067453) 3067453..3067698 - 246 WP_001164966.1 hypothetical protein -
J8I92_RS15155 (3067698) 3067698..3068516 - 819 WP_001560884.1 DUF932 domain-containing protein -
J8I92_RS15160 (3068634) 3068634..3068805 - 172 Protein_2978 DUF905 family protein -
J8I92_RS15165 (3068906) 3068906..3069361 - 456 WP_000581502.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14214.14 Da        Isoelectric Point: 6.4773

>T198304 WP_000854739.1 NZ_CP072688:c3064976-3064596 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGVPSQLINSIDILRARRATGLMTRDNYRTVNDITLGRHPEEAKQ

Download         Length: 381 bp

>T198304 NZ_CP096844:3521515-3521859 [Mycobacterium tuberculosis variant bovis]
TTGGCCGTGATCCTGCTCCCGCAGGTCGAACGGTGGTTCTTCGCGCTCAACAGGGATGCGATGGCCTCGGTCACCGGCGC
CATCGACCTGCTCGAAATGGAGGGGCCGACGTTGGGCCGCCCGGTGGTCGACAAAGTGAACGACTCAACGTTTCACAACA
TGAAGGAGCTGCGCCCCGCCGGCACCAGCATCCGGATCCTGTTCGCCTTCGACCCGGCCCGGCAGGCGATCCTGCTGCTG
GGCGGTGACAAGGCAGGCAACTGGAAACGCTGGTACGACAACAACATTCCAATCGCTGACCAGCGCTCCGAGAACTGGCT
GGCGAGCGAGCACGGAGGTGGATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13791.44 Da        Isoelectric Point: 4.7511

>AT198304 WP_001285482.1 NZ_CP072688:c3065397-3065023 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT198304 NZ_CP096844:3521856-3522185 [Mycobacterium tuberculosis variant bovis]
ATGACCATGGCCCGCAACTGGCGTGACATTCGCGCCGATGCCGTCGCGCAGGGCCGCGTGGATCTGCAGCGGGCCGCCGT
GGCACGCGAGGAGATGCGCGATGCCGTCCTGGCGCACCGCCTGGCCGAGATCCGCAAGGCGCTAGGCCACGCACGTCAGG
CCGACGTCGCGGCGCTGATGGGGGTCTCTCAGGCCCGTGTCTCCAAGCTGGAGAGCGGCGACCTGTCCCACACCGAACTC
GGCACCCTGCAGGCCTACGTTGCCGCCCTGGGCGGGCACCTGCGCATCGTCGCTGAGTTCGGCGAAAATACTGTCGAGCT
GACCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V687

Antitoxin

Source ID Structure
AlphaFold DB A0A0P7R0L9

References