Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 2585376..2586964 | Replicon | chromosome |
| Accession | NZ_CP072688 | ||
| Organism | Escherichia coli strain P4 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | B7MMY1 |
| Locus tag | J8I92_RS12550 | Protein ID | WP_001125475.1 |
| Coordinates | 2585642..2586964 (+) | Length | 441 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | - |
| Locus tag | J8I92_RS12545 | Protein ID | WP_001332145.1 |
| Coordinates | 2585376..2585642 (+) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J8I92_RS12530 (2581744) | 2581744..2583195 | + | 1452 | WP_000854636.1 | tagaturonate reductase | - |
| J8I92_RS12535 (2583392) | 2583392..2584306 | + | 915 | WP_001306069.1 | bestrophin family protein | - |
| J8I92_RS12540 (2584310) | 2584310..2585068 | - | 759 | WP_001286588.1 | trans-aconitate 2-methyltransferase | - |
| J8I92_RS12545 (2585376) | 2585376..2585642 | + | 267 | WP_001332145.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
| J8I92_RS12550 (2585642) | 2585642..2586964 | + | 1323 | WP_001125475.1 | type II toxin-antitoxin system serine/threonine protein kinase toxin HipA | Toxin |
| J8I92_RS12555 (2587143) | 2587143..2587409 | - | 267 | WP_001527024.1 | hypothetical protein | - |
| J8I92_RS12560 (2587420) | 2587420..2588214 | - | 795 | WP_001527023.1 | hypothetical protein | - |
| J8I92_RS12565 (2588282) | 2588282..2588704 | - | 423 | WP_001527022.1 | hypothetical protein | - |
| J8I92_RS12570 (2588804) | 2588804..2589250 | - | 447 | WP_000527682.1 | helix-turn-helix transcriptional regulator | - |
| J8I92_RS12575 (2589422) | 2589422..2590474 | + | 1053 | WP_000568107.1 | phage/plasmid replication protein, II/X family | - |
| J8I92_RS12580 (2590486) | 2590486..2590803 | + | 318 | WP_000073835.1 | DNA-binding protein | - |
| J8I92_RS12585 (2590806) | 2590806..2591057 | + | 252 | WP_001536107.1 | hypothetical protein | - |
| J8I92_RS12590 (2591092) | 2591092..2591325 | + | 234 | WP_000473544.1 | hypothetical protein | - |
| J8I92_RS12595 (2591411) | 2591411..2591725 | + | 315 | Protein_2469 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49426.24 Da Isoelectric Point: 8.9380
>T198302 WP_001125475.1 NZ_CP072688:2585642-2586964 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRRNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVMCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVKRFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRRNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVMCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVKRFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK
Download Length: 1323 bp
>T198302 NZ_CP096844:3146502-3146765 [Mycobacterium tuberculosis variant bovis]
GTGCCTTACACCGTGCGGTTCACCACAACCGCGCGTCGAGACCTCCACAAGCTGCCACCGCGAATCCTCGCGGCAGTGGT
CGAATTCGCGTTCGGCGATCTGTCGCGCGAGCCCCTGCGGGTGGGCAAGCCCCTTCGGCGCGAGTTGGCCGGCACGTTCA
GCGCGCGTCGCGGAACGTACCGCCTGCTGTACCGGATTGACGACGAGCACACAACGGTAGTGATCCTGCGCGTCGATCAC
CGCGCGGACATCTACCGCCGATAG
GTGCCTTACACCGTGCGGTTCACCACAACCGCGCGTCGAGACCTCCACAAGCTGCCACCGCGAATCCTCGCGGCAGTGGT
CGAATTCGCGTTCGGCGATCTGTCGCGCGAGCCCCTGCGGGTGGGCAAGCCCCTTCGGCGCGAGTTGGCCGGCACGTTCA
GCGCGCGTCGCGGAACGTACCGCCTGCTGTACCGGATTGACGACGAGCACACAACGGTAGTGATCCTGCGCGTCGATCAC
CGCGCGGACATCTACCGCCGATAG
Antitoxin
Download Length: 89 a.a. Molecular weight: 10016.44 Da Isoelectric Point: 6.2267
>AT198302 WP_001332145.1 NZ_CP072688:2585376-2585642 [Escherichia coli]
MMSFQKIYSPMQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPNNTSLTTFFKILQSLELSMTLCDAKNASPEA
TEQQDLEW
MMSFQKIYSPMQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPNNTSLTTFFKILQSLELSMTLCDAKNASPEA
TEQQDLEW
Download Length: 267 bp
>AT198302 NZ_CP096844:3146217-3146498 [Mycobacterium tuberculosis variant bovis]
ATGCGGATACTGCCGATTTCGACGATCAAGGGCAAGCTCAATGAGTTCGTCGACGCGGTCTCGTCGACACAGGACCAGAT
CACCATCACCAAGAACGGTGCACCCGCAGCCGTTCTGGTCGGCGCCGACGAGTGGGAATCGTTGCAGGAGACGCTGTACT
GGCTGGCGCAACCCGGAATCAGGGAGTCGATCGCTGAAGCCGACGCCGACATTGCCTCCGGCCGCACCTACGGCGAAGAC
GAGATCCGCGCCGAATTCGGCGTCCCGCGACGCCCCCACTGA
ATGCGGATACTGCCGATTTCGACGATCAAGGGCAAGCTCAATGAGTTCGTCGACGCGGTCTCGTCGACACAGGACCAGAT
CACCATCACCAAGAACGGTGCACCCGCAGCCGTTCTGGTCGGCGCCGACGAGTGGGAATCGTTGCAGGAGACGCTGTACT
GGCTGGCGCAACCCGGAATCAGGGAGTCGATCGCTGAAGCCGACGCCGACATTGCCTCCGGCCGCACCTACGGCGAAGAC
GAGATCCGCGCCGAATTCGGCGTCCCGCGACGCCCCCACTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|