Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1968025..1968856 Replicon chromosome
Accession NZ_CP072688
Organism Escherichia coli strain P4

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag J8I92_RS09500 Protein ID WP_000854814.1
Coordinates 1968025..1968399 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A366YXM1
Locus tag J8I92_RS09505 Protein ID WP_001518724.1
Coordinates 1968488..1968856 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8I92_RS09460 (1963421) 1963421..1964587 + 1167 WP_001297905.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
J8I92_RS09465 (1964706) 1964706..1965179 + 474 WP_001105376.1 DNA gyrase inhibitor SbmC -
J8I92_RS09470 (1965377) 1965377..1966435 + 1059 WP_001200894.1 FUSC family protein -
J8I92_RS09475 (1966607) 1966607..1966936 + 330 WP_000450409.1 DUF496 family protein -
J8I92_RS09480 (1967037) 1967037..1967360 - 324 WP_223216378.1 EutP/PduV family microcompartment system protein -
J8I92_RS09485 (1967339) 1967339..1967419 + 81 WP_023441679.1 hypothetical protein -
J8I92_RS09490 (1967708) 1967708..1967788 - 81 Protein_1859 hypothetical protein -
J8I92_RS09495 (1967834) 1967834..1968028 - 195 WP_000988601.1 DUF5983 family protein -
J8I92_RS09500 (1968025) 1968025..1968399 - 375 WP_000854814.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
J8I92_RS09505 (1968488) 1968488..1968856 - 369 WP_001518724.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
J8I92_RS09510 (1968930) 1968930..1969151 - 222 WP_000692323.1 DUF987 domain-containing protein -
J8I92_RS09515 (1969214) 1969214..1969690 - 477 WP_001186773.1 RadC family protein -
J8I92_RS09520 (1969706) 1969706..1970179 - 474 WP_000855075.1 antirestriction protein -
J8I92_RS09525 (1970442) 1970442..1971263 - 822 WP_001234710.1 DUF932 domain-containing protein -
J8I92_RS09530 (1971484) 1971484..1971894 - 411 WP_000846705.1 hypothetical protein -
J8I92_RS09535 (1971910) 1971910..1972563 - 654 WP_001535423.1 hypothetical protein -
J8I92_RS09540 (1972656) 1972656..1973833 + 1178 WP_152895938.1 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T198289 WP_000854814.1 NZ_CP072688:c1968399-1968025 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T198289 NZ_CP096844:c2356681-2356247 [Mycobacterium tuberculosis variant bovis]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCACAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13441.24 Da        Isoelectric Point: 4.7594

>AT198289 WP_001518724.1 NZ_CP072688:c1968856-1968488 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLSSDADAYPLDQAFPLLMKQLELMLTSG
ELNPRNQHTVTLYAKGLACEADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT198289 NZ_CP096844:c2356942-2356688 [Mycobacterium tuberculosis variant bovis]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A366YXM1

References