Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4556944..4557776 Replicon chromosome
Accession NZ_CP072687
Organism Escherichia coli strain YP3

Toxin (Protein)


Gene name yeeV Uniprot ID A0A2R9V8K2
Locus tag J8I95_RS22010 Protein ID WP_001468432.1
Coordinates 4557402..4557776 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID Q1R2L5
Locus tag J8I95_RS22005 Protein ID WP_001285575.1
Coordinates 4556944..4557312 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8I95_RS21970 (4552837) 4552837..4553517 + 681 WP_001282919.1 WYL domain-containing protein -
J8I95_RS21975 (4553665) 4553665..4554342 + 678 WP_001097301.1 hypothetical protein -
J8I95_RS21980 (4554348) 4554348..4554581 + 234 WP_001278287.1 DUF905 family protein -
J8I95_RS21985 (4554671) 4554671..4555489 + 819 WP_001175160.1 DUF932 domain-containing protein -
J8I95_RS21990 (4555580) 4555580..4556065 + 486 WP_000213697.1 antirestriction protein -
J8I95_RS21995 (4556080) 4556080..4556556 + 477 WP_001298074.1 RadC family protein -
J8I95_RS22000 (4556643) 4556643..4556864 + 222 WP_000692350.1 DUF987 domain-containing protein -
J8I95_RS22005 (4556944) 4556944..4557312 + 369 WP_001285575.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
J8I95_RS22010 (4557402) 4557402..4557776 + 375 WP_001468432.1 TA system toxin CbtA family protein Toxin
J8I95_RS22015 (4557773) 4557773..4558261 + 489 WP_000777545.1 DUF5983 family protein -
J8I95_RS22020 (4558273) 4558273..4558470 + 198 WP_000839281.1 DUF957 domain-containing protein -
J8I95_RS22025 (4558567) 4558567..4559136 + 570 WP_001290252.1 DUF4942 domain-containing protein -
J8I95_RS22030 (4559885) 4559885..4561423 + 1539 WP_001187191.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4538517..4569236 30719


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14102.04 Da        Isoelectric Point: 7.3526

>T198283 WP_001468432.1 NZ_CP072687:4557402-4557776 [Escherichia coli]
MNTLPDTHIREASHCQSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T198283 NZ_CP096844:c2205992-2205696 [Mycobacterium tuberculosis variant bovis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13709.52 Da        Isoelectric Point: 6.6258

>AT198283 WP_001285575.1 NZ_CP072687:4556944-4557312 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT198283 NZ_CP096844:c2206240-2205989 [Mycobacterium tuberculosis variant bovis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R9V8K2

Antitoxin

Source ID Structure
AlphaFold DB A0A454ABF5

References